Cell lines | Samples, IC50 values in μg/mL and degrees of resistancea (in brackets) | ||||
---|---|---|---|---|---|
Extracts | Doxorubicin | ||||
AAB | AAR | ACL | ACB | ||
CEM/ADR5000 | 6.53 ± 0.77 (4.50) | 6.52 ± 0.57 (6.65) | 22.57 ± 2.17 (2.81) | 34.87 ± 3.91 (2.77) | 108.00 ± 7.92 (975.60) |
MDA-MB-231-pcDNA | 5.99 ± 0.3 | 3.79 ± 0.44 | 29.51 ± 3.08 | 25.54 ± 3.01 | 0.61 ± 0.15 |
MDA-MB-231-BCRP Degree of resistance | 10.30 ± 1.22 (1.72) | 8.00 ± 1.01 (2.11) | 35.42 ± 3.35 (1.20) | 33.60 ± 2.14 (1.32) | 4.33 ± 0.26 (7.12) |
HCT116 (p53+/+) | 5.13 ± 0.64 | 4.40 ± 0.32 | 33.15 ± 2.87 | 29.07 ± 2.68 | 0.78 ± 0.16 |
HCT116 (p53−/−) Degree of resistance | 9.46 ± 0.88 (1.84) | 10.77 ± 0.79 (2.45) | >80 (>2.41) | >80 (2.75) | 2.25 ± 0.04 (2.88) |
U87MG | 6.29 ± 0.40 | 8.86 ± 0.69 | 38.63 ± 3.32 | >80 | 0.59 ± 0.08 |
U87MG.ΔEGFR Degree of resistance | 2.71 ± 0.35 (0.43) | 3.43 ± 0.48 (0.39) | 32.12 ± 1.19 (0.83) | 31.84 ± 2.36 (<0.40) | 3.38 ± 0.32 (5.76) |
HepG2 Degree of resistance | 7.54 ± 0.55 (3.87) | 6.84 ± 0.64 (4.26) | >80 | >80 | 2.12 ± 0.52 (>37.74) |
AML12 | 29.18 ± 3.03 | 29.14 ± 2.17 | >80 | >80 | >80 |