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Table 1 Published bioactivity and phytochemistry of the studied plants

From: Cytotoxicity of methanol extracts of 10 Cameroonian medicinal plants towards multi-factorial drug-resistant cancer cell lines

Species (family); Voucher
Traditional uses Parts used (% yield)b Bioactive or potentially bioactive components Bioactivity of crude extract
Albizia adianthifolia (Schum.) (Fabaceae); 24729/SRF/Cam Treatment skin diseases, bronchitis, inflamed eyes, tapeworm, headaches and sinusitis [33, 34] Leaves (9.88), bark (10.65) and roots (7.12) Adianthifoliosides A, B, D [30, 35], lupeol and aurantiamide acetate [32], prosapogenins [31] Antimicrobial effect of crude extract against Ec, Ef, Pa, Pm, Kp, Sa, Sf, St, Ca, Ct, Ck, Cg, Cl, Cn [32, 36]; aqueous extract: antioxidant [32, 37]
Alchornea cordifolia (Schum. & Thonn.) Müll.-Arg. (Euphorbiaceae); 9657/SRF/Cam Treat rheumatic pains, fever, wounds, diarrhea, convulsions, coughs, gonorrhoea, yaws, ulcer, rheumatic pains, bronchial troubles [38, 39] Leaves (7.84), bark (11.32) and roots (6.23) Alchornine, alchorneinone, gentisnic acid and yohimbine [38] Crude extract showed: spasmolytic [38], anti-inflammatory [40], anti-microbial [41],[42], anti-diarrheal [43] and analgesic [44] activities
Alchornea laxiflora (Benth.) Pax & K Hoffm. (Euphorbiaceae); 9661/SRF/Cam Treatment of inflammatory and infectious diseases, poliomyelitis and measles. [45, 46] Leaves (10.21), bark (13.17) and roots (5.58) Quercetin-7,4′-disulphate, quercetin, quercetin-3′,4′-disulphate, quercetin-3,4′-diacetate, rutin and quercetrin [45] Methanol fraction of leave extracts : antimicrobial on Ba, Bc, Ec, Kp, Pa, Pf, Sa, Ag, Af, As, Ca, Cp [47],[36]; Crude extract : antioxidant [48]
Boerhavia diffusa Lin (Nyctaginaceae); 15247/SRF/Cam Treatment of diabetes, asthma, bronchial infections [49] Whole plant (11.42) Boeravinones G, H [50] Crude extract of leaves: Antioxidant and hepatoprotective properties [51], antimicrobial activity of crude extract agains: Pa, Ec, St, Sf [52], Kp, Ea, Ps [36]
Combretum hispidum Laws (Combretaceae); 48289/HNC Treatment of stomach aches, diarrhea, gastro-intestinal disorders, liver complaints, skin infections, urinary tract infections [5355] Leaves (14.32), roots (8.47) Alkaloids, polyphenols, flavonoids, anthraquinones, coumarins, tannins, triterpenes, sterols ans saponins [36] Crude extract of bark: anti-hepatoxic, anti-inflammatory, antiparasitic, mollucidal effect [56], Antimicrobial effect of crude extract against Ec, Kp, Pa, Ea, Ps [36]
Eremomastax speciosa (Hochst.) Cufod. (Acanthaceae); 24165/SRF/Cam Haematopoietic, antidiarrhoeal, antiulcer, treatment of female infertility, dysentery, anemia, irregular menstruation, fracture, hemorrhoids and urinary tract infections [57, 58] Whole plant (14.69) Alkaloids, polyphenols, flavonoids, tannins, triterpenes, sterols ans saponins [42] Antimicrobial effect of crude extract against Ec, Sa, Ca [59], Ec, Pa, Ea, Ps [42]
Laportea aestuans (Linn.) Chew (Urticaceae); 34812/HNC Antihelmintic, treatment of headache, syphilitic yaws, fever, gonorrhea, rheumatism, menopausal disorder, antidote, asthma, hypertension, stomachage, diarrhea, wounds [60] Whole plant (8.82) Vanilic acid, gallic acid, ferulic acid, (6)-gingerol, capsaicin, rosemamic acid, tannic acid, p-coumaric acid, caffeic acid, scopoletin, catechin, resveratrol, genistein, apigenin, kaempherol, epicatechin, epigallocathechin, ellagic acid, myricitin acid, quercetin- 3, 7, 4-trimethyl ether, quercetin–3,7,3′,4′-trimethyl ether, artemetin, kaempferol–arabinoside, quercitrin, isoquercitrin, naringin, rutin, hesperidin, limonene, α-pinene, β-pinene, cis-ocimene, myrcene, citronellol, neryl acetate, malvidine, lycopene, carotene, lutein, hispogenin, diosgenin, neochlorogenin, hecogenin, [61, 62] Antimicrobial effect of crude extract against; K, Ec, Sa, Bs, St, Pa, Ca, [61, 63] Ec, Pa, Kp, Ea, Ps [42]
Laportea ovalifolia (Schum.) Chew (Urticaceae) 44306/HNC Treatment of headache, internal ulcers, diabetes, bronchitis and wired [64, 65] Leaves (12.13) and roots (6.17) Laportoside A and laportomide A [66] Crude extract of leaves: antidiabetic and hypolipidaemic effects [65], and crude extract against Ec, Kp, Pa, Ea, Ps [36]
Pennisetum purpureum Schumach. (Poaceae); 12525/SRF/Cam Diuretic, antivenomous, treatment of measles, wound healing [67] Whole plant (8.82) Alkaloids, polyphenols, flavonoids, tannins, triterpenes, sterols ans saponins [42] Antimicrobial effect of EO: Ec, Pa [67] and crude extract against Ec, Kp, Pa, Ea, Ps [42]
Spathodea campanulata P. Beauv. (Bignoniaceae) 22791/SRF/Cam Treatment of mental disorders, malaria, hemorrhoids, bacterial infections, HIV, poor blood circulation, gastro-intestinal diseases, urinary tract disorders [68] Leaves (16.13), bark (15.27) and roots (11.41) Carbohydrates, alkaloids, tannins, iridoid glucoside, phydroxy-benzoic acid, methyl p-hydroxy-benzoate [68, 69] Antimicrobial effect of against Pv, Ec, Kp [70], Pa, Ea, Ps [42]
  1. a(HNC): Cameroon National Herbarium; (SRF/Cam):Société des Réserves Forestières du Cameroun; byield calculated as the ratio of the mass of the obtained methanol extract/mass of the plant powder; EO Essential oil, As Aspergillus niger, Ag Aspergillus glaucus, Af Aspergillus flavus, Ba Bacillus anthracis, Bc Bacillus cereus, Bs Bacillus subtilis, Ca Candida albicans, Cg Candida glabrata, CK Candida krusei, Cl Candida lusitaniae, Cn Cryptococcus neoformans, Cp Candida pseudotropicalis, Ct Candida tropicalis, Ec Escherichia coli, Ea Enterobacter aerogenes, Ef Enterococcus faecalis, Kp Klebsiella pneumoniae, Pa Pseudomonas aeruginosa, Pf Pseudomonas fluorenscens, Pm Proteus mirabilis, Pv Proteus vulgaris, Ps Providencia stuartii, Sa Staphylococcus aureus, Sf Shigella flexneri, Se Salmonella enterica, St Salmonella typhi; Underline: disease states bearing relevance to cancer or cancer-like symptoms