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Table 5 Inhibition efficiency of drug alone and drug combination on AR activation (mU · min−1 · μg−1 protein) of HLECs induced by high glucose

From: Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract

gigantol (μg/mL) syringic acid (μg/mL)
0 0.125 0.625 1.25 2.5
0 16.34 ± 0.71* 13.11 ± 0.13 12.23 ± 0.68 11.21 ± 0.37 10.27 ± 0.29
0.1 12.98 ± 0.32 10.46 ± 0.23 9.79 ± 0.33 8.86 ± 0.19 8.45 ± 0.58
0.5 11.02 ± 0.63 10.06 ± 0.26 9.51 ± 0.15 8.62 ± 0.47 8.05 ± 0.36
1 10.52 ± 0.42 9.73 ± 0.54 9.06 ± 0.27 8.03 ± 0.36 7.24 ± 0.83
2 10.01 ± 0.76 9.33 ± 0.45 7.42 ± 0.52 6.79 ± 0.23 6.25 ± 0.37
  1. The AR activity in HLEC cultured in the normal group (5.56 mM glucose alone) was 5.35 mU · min−1 · μg−1 protein. The results given are for HLEC incubated with 50 mM glucose with the indicated additions, respectively. Data were expressed as mean ± SD (n = 3). * P < 0.05 vs all other groups