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Table 5 Inhibition efficiency of drug alone and drug combination on AR activation (mU · min−1 · μg−1 protein) of HLECs induced by high glucose

From: Investigation of synergistic mechanism and identification of interaction site of aldose reductase with the combination of gigantol and syringic acid for prevention of diabetic cataract

gigantol (μg/mL)

syringic acid (μg/mL)

0

0.125

0.625

1.25

2.5

0

16.34 ± 0.71*

13.11 ± 0.13

12.23 ± 0.68

11.21 ± 0.37

10.27 ± 0.29

0.1

12.98 ± 0.32

10.46 ± 0.23

9.79 ± 0.33

8.86 ± 0.19

8.45 ± 0.58

0.5

11.02 ± 0.63

10.06 ± 0.26

9.51 ± 0.15

8.62 ± 0.47

8.05 ± 0.36

1

10.52 ± 0.42

9.73 ± 0.54

9.06 ± 0.27

8.03 ± 0.36

7.24 ± 0.83

2

10.01 ± 0.76

9.33 ± 0.45

7.42 ± 0.52

6.79 ± 0.23

6.25 ± 0.37

  1. The AR activity in HLEC cultured in the normal group (5.56 mM glucose alone) was 5.35 mU · min−1 · μg−1 protein. The results given are for HLEC incubated with 50 mM glucose with the indicated additions, respectively. Data were expressed as mean ± SD (n = 3). * P < 0.05 vs all other groups