Fig. 1
From: Antiangiogenic and antihepatocellular carcinoma activities of the Juniperus chinensis extract
CBT-143-S-F6F7 inhibited angiogenesis. a CBT-143-S-F6F7 showed concentration-dependent inhibition the tube formation of HUVECs. b The net structure of HUVECs and the related total length of the net structure of HUVECs suppressed by CBT-143-S-F6F7 concentration-dependently. c CBT-143-S-F6F7 suppressed HUVEC migration by using a transwell assay. When treated with CBT-143-S-F6F7, less HUVECs stained with crystal violet were observed on lower side of membrane. d CBT-143-S-F6F7 inhibited angiogenesis in a Matrigel plug assay (Formation of red color in a Matrigel plug indicate vascular formation.) e CBT-143-S-F6F7 concentration-dependently inhibited the content of hemoglobin in the Matrigel plugs.*:P < 0.05 vs. vehicle group. f CBT-143-S-F6F7 concentration-dependently suppressed vessel formation in a CAM assay. The quantitative analysis of vessel formation was demonstrated using VDI as mentioned in Methods. *:P < 0.05 vs. vehicle group