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Table 2 Effect of SFEE on the levels of liver biomarkers compared to silymarin after CCl4 intoxication

From: Hepatoprotective activity of ethanolic extract of Salix subserrata against CCl4-induced chronic hepatotoxicity in rats

  Group I Group II Group III Group IV
Control CCl4 CCl4 + SFEE (150 mg/kg) CCl4 + Silymarin (100 mg/kg)
Albumin (mg/dl) 4.7 ± 0.034 3.2 ± 0.45+++ 4.7 ± 0.087** 4.5 ± 0.17**
Cholesterol (mg/dl) 72 ± 3.1 130 ± 12+++ 72 ± 2.5*** 68 ± 3.5***
Bilirubin (mg/dl) 0.11 ± 0.045 0.39 ± 0.03+++ 0.11 ± 0.031*** 0.087 ± 0.033**
Triglyceride (mg/dl) 71 ± 4.1 130 ± 6.9+++ 80 ± 6.8*** 75 ± 6.7***
ALT (U/L) 40 ± 3.1 100 ± 6.9 41 ± 2.4*** 42 ± 2.2***
AST (U/L) 100 ± 5.9 240 ± 23 110 ± 5.1*** 110 ± 4.0***
ALP (U/L) 24 ± 1.9 160 ± 10.6+++ 28.5 ± 2.1*** 26 ± 1.4***
LDH (U/L) 570 ± 42 1200 ± 56+++ 580 ± 52*** 600 ± 59***
  1. Values represent Mean ± SEM (n = 10)
  2. ALT Alanine aminotransferase, AST Aspartate aminotransferase, ALP Alkaline phosphatase, GSH Total thiol, LDH Lactate dehydrogenase
  3. ***p < 0.001 (compared to CCl4 (group II)) and +++ p < 0.001 (compared to control group I). No significant difference (p = 0.3 or higher) between group III (150 mg/kg SFEE) and group IV (silymarin), using one-way ANOVA test followed by Tukey-Kramer test
  4. **p < 0.01