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Table 1 Assessment of orally-administered SFEE on serum biochemical parameters in rats treated for 28 days

From: Hepatoprotective activity of ethanolic extract of Salix subserrata against CCl4-induced chronic hepatotoxicity in rats

  Group I Group II Group III Group IV Group V Group VI Group VII Group VIII
Control 50 mg/kg 100 mg/kg 150 /kg 250 mg/kg 500 mg/kg 750 mg/kg 1000 mg /kg
Albumin (mg/dl) 4.69 ± 0.12 4.65 ± 0.1 4.72 ± 0.27 4.63 ± 0.16 5.1 ± 1.2 4.53 ± 0.26 4.87 ± 0.19 4.92 ± 0.19
Cholesterol (mg/dl) 72 ± 3.07 73 ± 2.09 71 ± 3.6 71 ± 3.1 72 ± 5.7 73 ± 1.2 70 ± 1.7 74 ± 6.1
Bilirubin (mg/dl) 0.11 ± 0.03 0.12 ± 0.01 0.11 ± 0.02 0.11 ± 0.02 0.11 ± 0.02 0.13 ± 0.06 0.12 ± 0.08 0.13 ± 0.01
Triglycerides (mg/dl) 71 ± 2.5 72 ± 3.1 71 ± 2.3 69 ± 1.6 73 ± 1.5 71 ± 2.1 72 ± 3.2 73 ± 6.1
ALT (U/L) 42 ± 1.3 41 ± 2.3 44 ± 3.5 42 ± 2.6 43 ± 3.6 42 ± 3.1 44 ± 2.5 44 ± 3.1
AST (U/L) 101 ± 2.8 101 ± 3.8 99 ± 5.2 100 ± 3.7 102 ± 5.4 98 ± 3.8 102 ± 5.3 103 ± 7.3
ALP (U/L) 24 ± 2.1 24 ± 1.57 25 ± 1.5 24 ± 2.2 26 ± 1.2 25 ± 1.7 25 ± 1.4 24. ± 2.2
LDH (U/L) 578 ± 37 572 ± 39 587 ± 57 581 ± 48 601 ± 35 590 ± 45 600 ± 53 598 ± 65
GSH (μM/100 mg liver) 5.2 ± 0.87 5.2 ± 0.12 5.4 ± 0.45 5.3 ± 0.58 5.4 ± 0.97 5.1 ± 0.3 5.2 ± 0.4 5.23 ± 0.5
MDA (n mole/g liver) 17 ± 2.9 18 ± 3.2 16 ± 3.8 17.2 ± 4.1 17 ± 3.5 17.8 ± 2.8 18 ± 4.8 19 ± 3.7
Urea (U/L) 5.1 ± 0.68 5.3 ± 0.62 5.2 ± 0.76 5.2 ± 0.13 5.2 ± 0.56 5.3 ± 0.4 5.13 ± 0.34 5.3 ± 0.67
Creatinine (mg/dl) 25 ± 2.3 27 ± 2.1 25 ± 0.83 25 ± 3.1 26 ± 0.76 26.7 ± 0.7 27.1 ± 0.9 28.2 ± 3.7
  1. Values represent Mean ± SEM (n = 10)
  2. ALT Alanine aminotransferase, AST Aspartate aminotransferase, ALP Alkaline phosphatase, GSH Total thiol, MDA Malondialdehyde
  3. All groups compared to group I (healthy control group). No significant difference between group II, through VIII (50, 100, 150, 250, 500, 750 and 1000 mg/kg SFEE respectively) and group I (healthy control), p = 0.5 or higher using one-way Anova followed by Tukey-Kramer test