Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats

Sireeratawong, Seewaboon; Jaijoy, Kanjana; Khonsung, Parirat; Lertprasertsuk, Nirush; Ingkaninan, Kornkanok

doi:10.1186/s12906-016-1236-4

BMC Complementary Medicine and Therapies

Table 7 Biochemical parameters of female and male rats in chronic toxicity test

From: Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats

Biochemical parameter	Control			B. monnieri extract
Biochemical parameter	Control			30 mg/kg			60 mg/kg			300 mg/kg			1,500 mg/kg			Satellite group
Female rats
GLU (mg/dl)	177.30	±	5.66	159.90	±	7.50	147.50	±	6.55*	134.10	±	8.50*	132.20	±	7.96*	170.3	±	8.85
BUN (mg/dl)	16.12	±	1.99	16.54	±	0.41	15.76	±	1.23	16.47	±	0.44	27.50	±	11.31	21.32	±	0.53
CRE (mg/dl)	0.56	±	0.02	0.57	±	0.01	0.55	±	0.01	0.58	±	0.01	0.60	±	0.02	0.61	±	0.02*
TP (g/dl)	6.29	±	0.08	6.20	±	0.08	6.15	±	0.09	6.22	±	0.12	6.16	±	0.10	5.86	±	0.03*
ALB (g/dl)	3.20	±	0.03	3.27	±	0.03	3.27	±	0.03	3.20	±	0.05	3.12	±	0.04	3.18	±	0.05
T-BIL (mg/dl)	0.10	±	0.01	0.10	±	0.01	0.11	±	0.01	81.18	±	81.09	0.10	±	0.00	0.25	±	0.02
D-BIL (mg/dl)	0.18	±	0.02	0.17	±	0.02	0.23	±	0.03	0.28	±	0.08	0.22	±	0.03	0.11	±	0.01
AST (U/L)	195.60	±	26.12	220.20	±	22.37	162.70	±	9.09	213.40	±	21.86	178.20	±	21.36	204.80	±	21.98
ALT (U/L)	57.60	±	9.00	77.70	±	10.96	49.70	±	5.35	73.40	±	9.83	61.10	±	9.88	63.20	±	7.79
ALP (U/L)	43.20	±	2.92	40.60	±	3.03	41.90	±	3.22	48.00	±	7.90	48.10	±	6.03	43.10	±	3.94
Male rats
GLU (mg/dl)	209.10	±	8.67	209.40	±	15.59	181.40	±	18.86	219.60	±	14.18	196.40	±	9.49	174.20	±	8.07
BUN (mg/dl)	17.52	±	0.46	18.25	±	0.45	17.29	±	0.63	16.59	±	0.32	16.94	±	0.50	19.62	±	0.31*
CRE (mg/dl)	0.57	±	0.03	0.56	±	0.02	0.54	±	0.02	6.09	±	5.55	0.53	±	0.01	0.61	±	0.02
TP (g/dl)	6.11	±	0.12	5.85	±	0.15	6.19	±	0.09	6.11	±	0.10	6.37	±	0.13	6.25	±	0.18
ALB (g/dl)	3.07	±	0.05	3.03	±	0.06	3.06	±	0.03	3.07	±	0.05	3.10	±	0.04	3.21	±	0.06
T-BIL (mg/dl)	0.20	±	0.03	0.18	±	0.02	0.18	±	0.02	0.14	±	0.02	0.16	±	0.02	0.18	±	0.02
D-BIL (mg/dl)	0.09	±	0.01	0.09	±	0.00	0.10	±	0.01	0.09	±	0.00	0.08	±	0.01	0.18	±	0.07
AST (U/L)	193.00	±	13.81	158.60	±	9.13	152.30	±	13.61*	142.60	±	8.27*	146.80	±	10.34*	201.80	±	22.31
ALT (U/L)	63.20	±	6.35	61.90	±	5.82	54.60	±	5.27	51.30	±	2.86	54.40	±	3.99	83.40	±	9.42*
ALP (U/L)	55.80	±	2.51	53.20	±	2.28	52.90	±	1.59	55.10	±	2.61	61.10	±	2.22	64.90	±	3.40*

A satellite group was given the B. monnieri extract at 1,500 mg/kg daily over 270 days followed by no treatment for 28 days
GLU glucose, BUN blood urea nitrogen, CRE creatinine, TP total protein, ALB albumin, T-BIL total bilirubin, D-BIL direct bilirubin, AST aspartate aminotransferase, ALT alanine aminotransferase, ALP alkaline phosphatase
Values are expressed as mean ± S.E.M., n = 10. *Significantly different from control, p < 0.05

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