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Table 5 Hematological parameters of female rats in chronic toxicity test

From: Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats

Hematological parameter Control B. monnieri extract
30 mg/kg 60 mg/kg 300 mg/kg 1,500 mg/kg Satellite group
RBC (x106/μl) 8.96 ± 0.27 9.03 ± 0.37 8.80 ± 0.13 8.56 ± 0.20 8.98 ± 0.18 9.92 ± 0.20*
HB (g/dl) 16.36 ± 0.37 16.22 ± 0.30 16.24 ± 0.22 15.84 ± 0.29 16.41 ± 0.27 17.50 ± 0.26*
HCT (%) 50.00 ± 1.60 50.80 ± 2.12 48.80 ± 0.73 48.60 ± 1.05 50.20 ± 0.89 56.60 ± 0.98*
MCV (fl) 55.70 ± 0.30 56.10 ± 0.43 55.40 ± 0.27 56.50 ± 0.31 55.80 ± 0.59 57.00 ± 0.30*
MCH (pg) 18.30 ± 0.22 18.09 ± 0.44 18.41 ± 0.25 18.56 ± 0.27 18.30 ± 0.31 17.61 ± 0.13
MCHC (g/dl) 32.83 ± 0.45 32.18 ± 0.79 33.13 ± 0.38 32.82 ± 0.37 32.75 ± 0.38 30.90 ± 0.17*
PLT (x105/μl) 0.83 ± 0.05 0.85 ± 0.05 0.77 ± 0.02 0.73 ± 0.02 0.72 ± 0.09 0.68 ± 0.04*
WBC (x103/μl) 5.18 ± 0.34 4.96 ± 0.38 5.87 ± 0.36 6.32 ± 0.61 7.03 ± 0.63* 6.27 ± 0.67
NEU (x103/μl) 1.37 ± 0.16 1.28 ± 0.15 1.30 ± 0.14 1.53 ± 0.42 1.41 ± 0.19 2.03 ± 0.26
LYMP (x103/μl) 3.18 ± 0.39 3.40 ± 0.24 4.27 ± 0.28 9.59 ± 5.25* 5.31 ± 0.50 3.63 ± 0.58
MONO (x103/μl) 0.15 ± 0.03 0.23 ± 0.06 0.21 ± 0.06 0.27 ± 0.07 0.19 ± 0.03 0.23 ± 0.04
EOS (x103/μl) 0.04 ± 0.02 0.04 ± 0.03 0.09 ± 0.03 0.04 ± 0.02 0.06 ± 0.02 0.03 ± 0.02
BASO (x103/μl) 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00 0.00 ± 0.00
  1. A satellite group was given the B. monnieri extract at 1,500 mg/kg daily over 270 days followed by no treatment for 28 days
  2. RBC red blood cell count, HB hemoglobin, HCT hematocrit, MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, PLT platelet count, WBC white blood cell count, NEU neutrophil, LYMP lymphocyte, MONO monocyte, EOS eosinophil, BASO basophil
  3. Values are expressed as mean ± S.E.M., n = 10. *Significantly different from control, p < 0.05