From: Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats
Control | B. monnieri extract | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
30 mg/kg | 60 mg/kg | 300 mg/kg | 1,500 mg/kg | Satellite group | ||||||||||||||
Brain | 2.11 | ± | 0.03 | 2.16 | ± | 0.03 | 2.16 | ± | 0.04 | 2.14 | ± | 0.04 | 2.17 | ± | 0.04 | 2.11 | ± | 0.03 |
Lung | 2.34 | ± | 0.10 | 2.60 | ± | 0.13 | 2.58 | ± | 0.14 | 2.58 | ± | 0.20 | 3.59 | ± | 0.21* | 2.36 | ± | 0.13 |
Heart | 1.84 | ± | 0.07 | 1.89 | ± | 0.05 | 1.76 | ± | 0.03 | 1.79 | ± | 0.06 | 1.97 | ± | 0.07 | 1.67 | ± | 0.06* |
Liver | 15.80 | ± | 0.44 | 16.80 | ± | 0.34 | 14.22 | ± | 0.23* | 14.09 | ± | 0.56* | 14.61 | ± | 0.61 | 14.75 | ± | 0.37 |
Pancreas | 0.97 | ± | 0.06 | 1.05 | ± | 0.04 | 0.99 | ± | 0.04 | 1.05 | ± | 0.04 | 0.98 | ± | 0.04 | 0.96 | ± | 0.03 |
Spleen | 1.27 | ± | 0.04 | 1.21 | ± | 0.12 | 1.41 | ± | 0.14 | 1.08 | ± | 0.14 | 1.54 | ± | 0.13 | 0.94 | ± | 0.09 |
Adrenal | 0.04 | ± | 0.00 | 0.04 | ± | 0.00 | 0.05 | ± | 0.00 | 0.04 | ± | 0.00 | 0.04 | ± | 0.00 | 0.04 | ± | 0.00 |
Kidney | 1.86 | ± | 0.04 | 2.03 | ± | 0.06* | 1.82 | ± | 0.04 | 1.76 | ± | 0.04 | 1.76 | ± | 0.06 | 1.74 | ± | 0.03 |
Testis | 2.13 | ± | 0.03 | 2.11 | ± | 0.09 | 2.11 | ± | 0.03 | 2.13 | ± | 0.03 | 2.05 | ± | 0.07 | 2.00 | ± | 0.04 |
Epididymis | 0.86 | ± | 0.02 | 0.93 | ± | 0.03 | 0.99 | ± | 0.03* | 1.04 | ± | 0.06* | 0.93 | ± | 0.03 | 0.87 | ± | 0.02 |