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Table 4 Organ weight (g) of male rats in chronic toxicity test

From: Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats

  Control B. monnieri extract
30 mg/kg 60 mg/kg 300 mg/kg 1,500 mg/kg Satellite group
Brain 2.11 ± 0.03 2.16 ± 0.03 2.16 ± 0.04 2.14 ± 0.04 2.17 ± 0.04 2.11 ± 0.03
Lung 2.34 ± 0.10 2.60 ± 0.13 2.58 ± 0.14 2.58 ± 0.20 3.59 ± 0.21* 2.36 ± 0.13
Heart 1.84 ± 0.07 1.89 ± 0.05 1.76 ± 0.03 1.79 ± 0.06 1.97 ± 0.07 1.67 ± 0.06*
Liver 15.80 ± 0.44 16.80 ± 0.34 14.22 ± 0.23* 14.09 ± 0.56* 14.61 ± 0.61 14.75 ± 0.37
Pancreas 0.97 ± 0.06 1.05 ± 0.04 0.99 ± 0.04 1.05 ± 0.04 0.98 ± 0.04 0.96 ± 0.03
Spleen 1.27 ± 0.04 1.21 ± 0.12 1.41 ± 0.14 1.08 ± 0.14 1.54 ± 0.13 0.94 ± 0.09
Adrenal 0.04 ± 0.00 0.04 ± 0.00 0.05 ± 0.00 0.04 ± 0.00 0.04 ± 0.00 0.04 ± 0.00
Kidney 1.86 ± 0.04 2.03 ± 0.06* 1.82 ± 0.04 1.76 ± 0.04 1.76 ± 0.06 1.74 ± 0.03
Testis 2.13 ± 0.03 2.11 ± 0.09 2.11 ± 0.03 2.13 ± 0.03 2.05 ± 0.07 2.00 ± 0.04
Epididymis 0.86 ± 0.02 0.93 ± 0.03 0.99 ± 0.03* 1.04 ± 0.06* 0.93 ± 0.03 0.87 ± 0.02
  1. A satellite group was given the B. monnieri extract at 1,500 mg/kg daily over 270 days followed by no treatment for 28 days
  2. Values are expressed as mean ± S.E.M., n = 10. *Significantly different from control, p < 0.05