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Table 4 Organ weight (g) of male rats in chronic toxicity test

From: Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats

 

Control

B. monnieri extract

30 mg/kg

60 mg/kg

300 mg/kg

1,500 mg/kg

Satellite group

Brain

2.11

±

0.03

2.16

±

0.03

2.16

±

0.04

2.14

±

0.04

2.17

±

0.04

2.11

±

0.03

Lung

2.34

±

0.10

2.60

±

0.13

2.58

±

0.14

2.58

±

0.20

3.59

±

0.21*

2.36

±

0.13

Heart

1.84

±

0.07

1.89

±

0.05

1.76

±

0.03

1.79

±

0.06

1.97

±

0.07

1.67

±

0.06*

Liver

15.80

±

0.44

16.80

±

0.34

14.22

±

0.23*

14.09

±

0.56*

14.61

±

0.61

14.75

±

0.37

Pancreas

0.97

±

0.06

1.05

±

0.04

0.99

±

0.04

1.05

±

0.04

0.98

±

0.04

0.96

±

0.03

Spleen

1.27

±

0.04

1.21

±

0.12

1.41

±

0.14

1.08

±

0.14

1.54

±

0.13

0.94

±

0.09

Adrenal

0.04

±

0.00

0.04

±

0.00

0.05

±

0.00

0.04

±

0.00

0.04

±

0.00

0.04

±

0.00

Kidney

1.86

±

0.04

2.03

±

0.06*

1.82

±

0.04

1.76

±

0.04

1.76

±

0.06

1.74

±

0.03

Testis

2.13

±

0.03

2.11

±

0.09

2.11

±

0.03

2.13

±

0.03

2.05

±

0.07

2.00

±

0.04

Epididymis

0.86

±

0.02

0.93

±

0.03

0.99

±

0.03*

1.04

±

0.06*

0.93

±

0.03

0.87

±

0.02

  1. A satellite group was given the B. monnieri extract at 1,500 mg/kg daily over 270 days followed by no treatment for 28 days
  2. Values are expressed as mean ± S.E.M., n = 10. *Significantly different from control, p < 0.05