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Table 3 Organ weight (g) of female rats in chronic toxicity test

From: Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats

  Control B. monnieri extract
30 mg/kg 60 mg/kg 300 mg/kg 1,500 mg/kg Satellite group
Brain 1.97 ± 0.02 1.94 ± 0.03 1.94 ± 0.03 2.07 ± 0.04* 2.08 ± 0.02* 2.01 ± 0.03
Lung 2.16 ± 0.26 2.16 ± 0.26 2.00 ± 0.14 2.14 ± 0.13 2.32 ± 0.19 2.00 ± 0.13
Heart 1.27 ± 0.05 1.22 ± 0.03 1.24 ± 0.04 1.38 ± 0.09 1.36 ± 0.06 1.31 ± 0.05
Liver 9.90 ± 0.32 9.55 ± 0.28 8.71 ± 0.30* 9.72 ± 0.23 9.33 ± 0.29 9.54 ± 0.27
Spleen 0.83 ± 0.03 0.81 ± 0.03 0.74 ± 0.03 0.83 ± 0.03 0.84 ± 0.04 0.79 ± 0.04
Pancreas 1.03 ± 0.09 1.09 ± 0.08 1.21 ± 0.14 1.34 ± 0.13 1.42 ± 0.14* 0.98 ± 0.12
Adrenal 0.04 ± 0.00 0.04 ± 0.00 0.05 ± 0.00 0.04 ± 0.00 0.04 ± 0.00 0.04 ± 0.00
kidney 1.27 ± 0.02 1.28 ± 0.02 1.20 ± 0.03 1.22 ± 0.02 1.24 ± 0.04 1.25 ± 0.03
Ovary 0.07 ± 0.00 0.08 ± 0.00 0.09 ± 0.01* 0.09 ± 0.01* 0.09 ± 0.01* 0.07 ± 0.00
Uterus 1.18 ± 0.14 1.36 ± 0.33 1.01 ± 0.07 0.96 ± 0.09 0.86 ± 0.05 1.13 ± 0.10
  1. A satellite group was given the B. monnieri extract at 1,500 mg/kg daily over 270 days followed by no treatment for 28 days
  2. Values are expressed as mean ± S.E.M., n = 10. *Significantly different from control, p < 0.05