From: Acute and chronic toxicities of Bacopa monnieri extract in Sprague-Dawley rats
Control | B. monnieri extract | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
30 mg/kg | 60 mg/kg | 300 mg/kg | 1,500 mg/kg | Satellite group | ||||||||||||||
Brain | 1.97 | ± | 0.02 | 1.94 | ± | 0.03 | 1.94 | ± | 0.03 | 2.07 | ± | 0.04* | 2.08 | ± | 0.02* | 2.01 | ± | 0.03 |
Lung | 2.16 | ± | 0.26 | 2.16 | ± | 0.26 | 2.00 | ± | 0.14 | 2.14 | ± | 0.13 | 2.32 | ± | 0.19 | 2.00 | ± | 0.13 |
Heart | 1.27 | ± | 0.05 | 1.22 | ± | 0.03 | 1.24 | ± | 0.04 | 1.38 | ± | 0.09 | 1.36 | ± | 0.06 | 1.31 | ± | 0.05 |
Liver | 9.90 | ± | 0.32 | 9.55 | ± | 0.28 | 8.71 | ± | 0.30* | 9.72 | ± | 0.23 | 9.33 | ± | 0.29 | 9.54 | ± | 0.27 |
Spleen | 0.83 | ± | 0.03 | 0.81 | ± | 0.03 | 0.74 | ± | 0.03 | 0.83 | ± | 0.03 | 0.84 | ± | 0.04 | 0.79 | ± | 0.04 |
Pancreas | 1.03 | ± | 0.09 | 1.09 | ± | 0.08 | 1.21 | ± | 0.14 | 1.34 | ± | 0.13 | 1.42 | ± | 0.14* | 0.98 | ± | 0.12 |
Adrenal | 0.04 | ± | 0.00 | 0.04 | ± | 0.00 | 0.05 | ± | 0.00 | 0.04 | ± | 0.00 | 0.04 | ± | 0.00 | 0.04 | ± | 0.00 |
kidney | 1.27 | ± | 0.02 | 1.28 | ± | 0.02 | 1.20 | ± | 0.03 | 1.22 | ± | 0.02 | 1.24 | ± | 0.04 | 1.25 | ± | 0.03 |
Ovary | 0.07 | ± | 0.00 | 0.08 | ± | 0.00 | 0.09 | ± | 0.01* | 0.09 | ± | 0.01* | 0.09 | ± | 0.01* | 0.07 | ± | 0.00 |
Uterus | 1.18 | ± | 0.14 | 1.36 | ± | 0.33 | 1.01 | ± | 0.07 | 0.96 | ± | 0.09 | 0.86 | ± | 0.05 | 1.13 | ± | 0.10 |