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Table 1 IC50 values for P. curatellifolia, C. zeyheri and ethacrynic acid determined from direct interactions with GST in vitro. The IC50 values were determined by reading the concentration at 50 % inhibition from the dose response graphs

From: In vivo and in vitro inhibition of rat liver glutathione transferases activity by extracts from Combretum zeyheri (Combretaceae) and Parinari curatellifolia (Chrysobalanaceae)

Organ Extract IC50 (μg/ml) ETA IC50 (μg/ml)
  Parinari curatellifolia   
Liver Aqueous 24 6
Liver Ethanol 12 10
Kidney Aqueous 52 7.4
Kidney Ethanol 52 3.7
  Combretum zeyheri   
Liver Aqueous 68 5.4
Liver Ethanol 1.3 10
Kidney Aqueous 80 10
Kidney Ethanol 1.4 3.1
  1. The IC50 values were obtained from Figs. 47. Each of the value was obtained from thesigmoidal dose–response curves as the concentration of the inhibitor was increased and are the mean of 4 values