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Fig. 2 | BMC Complementary and Alternative Medicine

Fig. 2

From: Oxymatrine inhibits aldosterone-induced rat cardiac fibroblast proliferation and differentiation by attenuating smad-2,-3 and-4 expression: an in vitro study

Fig. 2

Inhibitory effect of OMT on ALD-induced cardiac fibroblast proliferation. Cardiac fibroblasts were pretreated with 7.57 × 10−4 mol/L [High] or 3.78 × 10−4 mol/L [Low] OMT or without OMT for 2 h, and then coincubated with ALD (1 × 10−8 mol/L) for 46 h. a Cell viability was determined using the MTT assay. b Collagen fibers were visualized using Masson staining. Representative images of collagen fibers (green or blue), myocardial fibers (red), erythrocytes (orange), and nuclei (blue): (i) Control; (ii) ALD; (iii) OMT (Low); (iv) OMT (High). Results are means ± SEM of three independent experiments (*P < 0.05, **P < 0.01 vs. control group; # P < 0.05, ## P < 0.01 vs. ALD alone, n = 5)

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