Parameters
|
Groups
|
Baseline
|
Week 12
|
Week 24
|
---|
24 h UP (g/24 h)
|
TSF
|
1.0 ± 0.7
|
0.5 ± 0.5a
|
0.5 ± 0.5a
|
Placebo
|
0.9 ± 0.6
|
0.6 ± 0.6
|
0.7 ± 0.7
|
BUN (mmol/L)
|
TSF
|
6.0 ± 1.7
|
6.0 ± 1.7
|
6.0 ± 1.9
|
Placebo
|
6.1 ± 1.1
|
6.9 ± 1.6
|
7.2 ± 1.7
|
Scr (μmol/L)
|
TSF
|
74.9 ± 20.7
|
72.6 ± 22.6
|
73.5 ± 18.9
|
Placebo
|
79.4 ± 18.2
|
84.0 ± 17.4
|
83.1 ± 16.4
|
eGFR (ml/min/1.73 m2)
|
TSF
|
104.1 ± 32.8
|
102.7 ± 37.7
|
97.3 ± 25.8
|
Placebo
|
96.2 ± 30.0
|
91.3 ± 30.1
|
92.3 ± 32.2
|
ln plasma L-FABP (μg/ml)
|
TSF
|
1.7 ± 1.0
|
1.3 ± 1.3
|
1.5 ± 0.9
|
Placebo
|
1.6 ± 1.2
|
0.8 ± 1.4
|
1.2 ± 1.0
|
- All values expressed as mean ± SD
-
a
P < 0.05 compared with baseline of the same group (Paired t test)
- Abbreviations: BUN blood urea nitrogen, eGFR estimated glomerular filtration rate, ln-serum L-FABP ln-transformed serum liver-type fatty acid binding protein, Scr serum creatinine, UAER urinary albumin excretion rate