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Table 3 Influence of A. podagraria tincture and metformin on plasma values of lipid metabolism in rats receiving dexamethasone; Mean ± S.E.M; Q50 (Q25–Q75), n = 5–6 in each group

From: The influence of goutweed (Aegopodium podagraria L.) tincture and metformin on the carbohydrate and lipid metabolism in dexamethasone-treated rats

 

Total cholesterol, mmol/l

HDL cholesterol, mmol/l

LDL cholesterol, mmol/l

VLDL cholesterol, mmol/l

Atherogenic index

Total lipids, g/l

Intact control

2.38 ± 0.20

2.36

(2.20–2.51)

1.72 ± 0.13

1.64

(1.47–1.93)

0.62 ± 0.05

0.58

(0.57–0.66)

0.20 ± 0.02

0.20

(0.17–0.25)

0.39 ± 0.07

0.44

(0.26–0.50)

2.48 ± 0.18

2.56

(2.10–2.70)

Dexamethasone

2.71 ± 0.30

2.64

(2.20–3.02)

2.03 ± 0.22

2.16

(1.73–2.20)

0.55 ± 0.08

0.59

(0.47–0.59)

0.30 ± 0.04*

0.32

(0.24–0.36)

0.42 ± 0.04

0.42

(0.38–0.45)

2.82 ± 0.23

2.88

(2.61–2.94)

Dexamethasone + metformin, 50 mg/kg

2.62 ± 0.19

2.49

(2.32–2.82)

2.17 ± 0.14

2.20

(1.89–2.29)

0.31 ± 0.10

0.27

(0.23–0.35)

0.30 ± 0.04*

0.28

(0.25–0.34)

0.21 ± 0.06****

0.23

(0.10–0.25)

2.60 ± 0.26

2.54

(2.13–2.77)

Dexamethasone + A. podagraria tincture, 1 ml/kg

2.80 ± 0.15*

2.76

(2.53–2.84)

2.31 ± 0.18**

2.11

(2.07–2.36)

0.24 ± 0.05***,****, *******

0.28

(0.18–0.33)

0.24 ± 0.02

0.26

(0.23–0.28)

0.22 ± 0.03*****,******

0.23

(0.21–0.25)

2.91 ± 0.29

2.79

(2.41–3.16)

Dexamethasone + metformin.

50 mg/kg + A. podagraria tincture, 1 ml/kg

2.92 ± 0.11*

2.87

(2.78–2.92)

2.19 ± 0.06*

2.12

(2.09–2.23)

0.51 ± 0.08

0.43

(0.38–0.66)

0.22 ± 0.03

0.20

(0.16–0.25)

0.33 ± 0.03****

0.33

(0.28–0.38)

2.61 ± 0.17

2.51

(2.35–2.83)

  1. * – p < 0.05 compared to intact control; ** – p < 0.02 compared to intact control; *** – p < 0.01 compared to intact control
  2. **** – p < 0.05 compared to dexamethasone (untreated); ***** – p < 0.01 compared to dexamethasone (untreated)
  3. ****** – p < 0.05 compared to the group receiving metformin and A. podagraria tincture
  4. ******* – p < 0.02 compared to the group receiving metformin and A. podagraria tincture
  5. Medians are highlighted in bold