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Table 1 Influence of A. podagraria tincture and metformin on the results of oral glucose tolerance test in rats receiving dexamethasone; Mean ± S.E.M; Q50 (Q25–Q75), n = 5–6 in each group

From: The influence of goutweed (Aegopodium podagraria L.) tincture and metformin on the carbohydrate and lipid metabolism in dexamethasone-treated rats

Groups Plasma glucose during oral glucose tolerance test, mmol/l AUC, mmol × min/l Average glycemia value, mmol/l
Basal level 30 min 60 min 120 min
Intact control 4.38 ± 0.54
4.91
(3.42–5.34)
5.08 ± 0.42
5.34
(4.48–5.83)
6.37 ± 0.77
6.60
(5.60–6.83)
3.91 ± 0.35
3.84
(3.54–4.06)
622 ± 52.8
682
(551–707)
4.93 ± 0.39
5.34
(4.56–5.44)
Dexamethasone 6.01 ± 0.56
5.44
(4.98–6.68)
7.56 ± 0.72***
6.60
(6.58–7.86)
7.23 ± 0.54
6.60
(6.25–8.15)
6.22 ± 0.43***
5.87
(5.55–6.63)
829 ± 54.9*
785
(720–935)
6.75 ± 0.44**
6.49
(5.83–7.77)
Dexamethasone + metformin, 50 mg/kg 6.27 ± 0.53
6.68
(5.18–7.14)*****
6.33 ± 0.73
6.58
(5.27–7.04)
6.09 ± 0.76
6.25
(5.20–6.70)
4.93 ± 0.33****
4.91
(4.91–5.11)
701 ± 69.1
708
(650–742)
5.83 ± 0.53
5.69
(5.64–6.14)
Dexamethasone + A. podagraria tincture, 1 ml/kg 5.31 ± 0.58
4.78
(4.31–5.81)
8.20 ± 1.46*
6.49
(5.92–9.49)
7.18 ± 1.27
6.00
(5.13–8.25)
6.07 ± 1.05
6.24
(4.79–7.95)
831 ± 136
724
(611–980)
6.69 ± 1.05
5.88
(5.00–7.85)
Dexamethasone + metformin, 50 mg/kg + A. podagraria tincture, 1 ml/kg 4.24 ± 0.62
4.35
(3.26–5.17)
6.68 ± 0.74*
7.53
(6.02–7.68)
5.26 ± 0.72****
6.03
(3.66–6.40)
4.94 ± 0.78
5.11
(4.27–6.29)
649 ± 62.1
638
(576–757)
5.28 ± 0.45****
5.12
(5.11–5.82)
  1. * – p < 0.05 compared to intact control; ** – p < 0.02 compared to intact control; *** – p < 0.01 compared to intact control
  2. **** – p < 0.05 compared to dexamethasone (untreated); ***** – p < 0.05 compared to the group receiving metformin and A. podagraria tincture
  3. Medians are highlighted in bold