Fig. 4

The expression of retinal angiogenesis-related proteins in OIR mice. Expression of proangiogenic and antiangiogenic factors in the retina were analyzed using protein arrays and quantified using ImageJ software. Proteins for which expression was modulated in COE-treated retinas are indicated by numbers. Nor, normal control mice; OIR, saline-treated OIR mice and COE, OIR mice treated with 100 mg/kg COE. 1: AREG, amphiregulin; 2: ANG, angiogenin; 3: DLL4, Delta like ligand 4; 4: IGFBP-2, insulin-like growth factor binding protein 2; 5: VEGF: Vascular endothelial growth factor. The bar graph values represent the mean ± SE (n = 3; ^# \( p \) < 0.05 vs. the normal control mice, *p < 0.05 vs. the saline-treated OIR mice)