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Table 3 Cytotoxicity of NDL, each ingredient and two- or three-ingredient combinations on MCF-7 cells

From: Selective cytotoxicity of a Vietnamese traditional formula, Nam Dia long, against MCF-7 cells by synergistic effects

  Inh % CI of Fa = 0.5
  xCELLigence SRB
NDL 78.88 ± 2.17 35.41 ± 4.17 0.55
Pa −4.84 ± 2.02 −7.48 ± 0.38  
Vu −6.62 ± 0.60 −2.76 ± 2.13  
Vr 7.39 ± 0.21 −4.32 ± 1.94  
Sa 17.06 ± 2.36 - 4.77 ± 0.91  
Sa-Pa 22.21 ± 1.46 0.12 ± 4.39 1.64
Sa-Vu 23.55 ± 2.92 −5.10 ± 0.76 1.35
Sa-Vr 21.56 ± 9.70 −2.63 ± 1.04 0.41
Vr-Pa 12.31 ± 1.36 −4.26 ± 3.04 0.51
Vr-Vu −2.96 ± 2.55 −5.36 ± 0.96 1.21
Vu-Pa 11.73 ± 2.88 −3.13 ± 4.10 0.92
Sa-Vu-Pa 29.80 ± 3.16 −1.07 ± 1.79 1.17
Sa-Vr-Pa 29.44 ± 5.95 −0.81 ± 2.23 0.78
Sa-Vr-Vu 45.31 ± 4.75 −0.30 ± 1.94 0.76
Vr-Vu-Pa 11.49 ± 4.13 −13.47 ± 0.89 0.73
  1. MCF-7 cells were treated with NDL at the IC50 concentration, ingredients and the combinations at concentrations equivalent to the IC50 of NDL for 48 h. Cytotoxicity was measured by xCELLigence and SRB assay. CI of the two- and three-ingredient combinations were calculated by the Chou-Talalay method