Fig. 3

Oral administration of Cortex Phellodendri provides protection against lethal infection with divergent influenza A subtype in BALB/c mice. CP were orally administered to 5-week-old female BALB/c mice (0.8 μg/g body weight) in a total volume of 200 μl at 1, 3 and 5 days before infection with 5MLD₅₀ a H1N1, b H5N2, c H7N3 and d H9N2 Influenza A subtypes. PBS (200 μl) was orally administered to control groups. Percent survival and weight changes after challenge were recorded until 13 dpi. e Virus titers in lung tissues of H1N1 infected mice were measured by TCID₅₀ at 3 and 5 dpi. (*P < 0.05 indicates a significant difference between groups)