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Fig. 5 | BMC Complementary and Alternative Medicine

Fig. 5

From: Anti-allodynic effect of intrathecal processed Aconitum jaluense is associated with the inhibition of microglial activation and P2X7 receptor expression in spinal cord

Fig. 5

Intrathecal (i.t.) PA attenuated the increase in P2X7R and Iba-1 expression in the dorsal horn of the spinal cord seven days following L5 SNL. P2X7R immunoreactivity (green) was increased on the ipsilateral side (b) compared with the contralateral side (a). Expression of Iba1 in microglia (red) within the dorsal horn was significantly increased on the ipsilateral side (f) compared with the contralateral side (e). Both the increase in immunoreactivity to P2X7R and Iba-1 were attenuated by i.t. PA treatment (c, g), which was analyzed and depicted by bar graphs showing mean fluorescence intensity (d, h). N = 4 animals/group for all bars. Scale bar, 25 μm. *P < 0.05 vs. SNL/PA

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