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Table 1 Characteristics of included studies

From: Clinical effects of a standardized Chinese herbal remedy, Qili Qiangxin, as an adjuvant treatment in heart failure: systematic review and meta-analysis

ID (Author year) Disease Setting (in/out patients) Diagnosis criteria Sample size Age-T Age-C Men-% Course of treatment
Bai LQ 2013 HF in NYHA 40 45 ± 3.7 52 ± 4.2 57.5 3M
Cai RF 2013 CHF NA CMA 2009; MoH 2002; Framingham criteria; NYHA 50 52-80 52-81 54 4W
Cai YP 2013 CHF in or out Framingham criteria; NYHA 108 73.2 ± 11.5 60.19 6M
Chen L 2009 CHF in ACC/AHA 1995; MoH 2002; NYHA 61 67.2 ± 11.5 63.1 ± 13.8 57.38 4W
Chen TC 2013 CHF NA CMA 2007; NYHA 52 71-92 68-91 53.85 4W
Chen WQ 2012 CHF in or out CMA 2007; NYHA 120 58 ± 14 57 ± 14 59.17 6M
Chen XH 2014 HF NA CMA 2014 60 63 ± 10 62 ± 11 52.17 6M
Cheng XD 2013 ischemic heart failure in ACC/AHA criteria; NYHA 90 56.4 ± 6.2 54.2 ± 5.9 55.56 6W
Cui LL 2012 CHF in CMA 2007; NYHA 68 59.41 ± 9.68 58.6 ± 7.71 48.53 5M
Dai JX 2013 chronic congestive heart failure NA Guidelines for the Diagnosis and Treatment of Cardiovascular Disease 2006 100 70.2 58 4W
Ding LB 2010 HF in Internal Medicine 2004; MoH 2002 43 45 ± 12.2 42 ± 11.3 55.81 2M
Ding SY 2013 CHF NA Practical Internal Medicine 2001; NYHA 72 48-82 51-79 45.83 4W
Dong MX 2013 chronic congestive heart failure in Practical Internal Medicine 2001; NYHA 114 71.5   59.65 4W
Du YK 2014 diastolic heart failure out CMA 2007 102 60-86 59-82 39.22 30D
Duan JH 2010 CHF NA Clinical Cardiology 1996 61 63.4 ± 10.3 61.5 ± 8.7 72.13 3M
Fan J 2013a CHF NA Internal Medicine 2008; NYHA 86 68.1 ± 9.5 68.7 ± 9.6 55.81 2M
Feng QT 2013 chronic congestive heart failure out Framingham criteria 42 55.6 ± 10.32 54.66 ± 10.41 59.52 6M
Fu JZ 2012 CHF   Internal Medicine 2004; NYHA 60 77.3 ± 10.2 78.0 ± 10.1 58.33 3M
Gao JB 2011 chronic congestive heart failure in or out MoH 2002 167 58 ± 11 58.08 4W
Gu XM 2009 CHF in or out AHA criteria 38 52 ± 9 48 ± 10.6 68.42 2M
Gu XM 2013 CHF in or out ACC/AHA 2005; NYHA 65 57 ± 18.5 56 ± 16 66.15 4W
Gu YY 2012 CHF in or out NYHA 100 65.5 ± 10.1 62.3 ± 12.5 58.57 6M
Guan SY 2012 CHF NA Consensus for diagnosis and treatment of heart failure with normal ejection fraction in China 2010 82 56 ± 13 54 ± 13 42.68 8W
Guan SY 2013 CHF NA CMA 2007 72 55 ± 12 54 ± 13 52.78 12W
Guo P 2014 CHF NA ACC/AHA criteria; NYHA 90 71.6 ± 4.5 72 ± 3.5 58.7 3M
Guo SL 2011 chronic congestive heart failure in CMA 2007 120 60-80 60 3M
Guo WB 2013 chronic congestive heart failure in CHF criteria 1979 70 61.5 ± 9.12 57.4 ± 8.97 57.14 8W
Hu B 2013 CHF in or out Framingham criteria 80 39-75 36-76 78.75 3M
Huang B 2010 chronic congestive heart failure NA Framingham criteria; NYHA 100 61.2 ± 11.8 60.8 ± 12.5 60 6M
Huang YQ 2012 chronic congestive heart failure NA Internal Medicine 2004 46 60 ± 7.5 58 ± 7.8 47.83 4W
Huang Z 2014 CHF in or out CMA 2007; NYHA 60 35-74 35-74 58.33 12W
Jin Y 2012 heart failure derived from ischemic cardiomyopathy NA ICM criteria (Felker GM) 2002; NYHA 100 62.0 ± 15.2 63.0 ± 13.9 47 12W
Jing GJ 2009 CHF in or out WHO criteria; CMA 2002; MoH 2002 60 62.0 ± 3.5 63 ± 4.0 58.33 4W
Kuang JB 2008 CHF NA ESC criteria 106 71.6 45.16 8W
Li DW 2013 chronic congestive heart failure in NYHA 78 66 51.28 12W
Li GM 2011 chronic congestive heart failure in or out Framingham criteria; NYHA 120 72.5 71.8 56.67 4W
Li LC 2013 heart failure derived from ischemic cardiomyopathy NA NYHA 110 61 ± 13 63 ± 12 54.55 4W
Li P 2011 CHF in or out CMA 2002;NYHA 76 66.1 ± 7.8 66.3 ± 7.2 59.21 3M
Li Q 2014 HF NA NYHA 120 71.4 ± 8.0 70.2 ± 7.1 70.59 6M
Li RY 2010a CHF NA NYHA 86 68.4 ± 1.3 68.1 ± 1.3 67.44 4W
Li SQ 2014 CHF in or out CMA 2007; NYHA 147 41.2 ± 12.5 39.8 ± 13.2 40.82 2M
Li SZ 2009 congestive heart failure NA NYHA 39 62 ± 7 56.41 4W
Li T 2010 CHF in Boston criteria; NYHA 44 56 ± 14 56.82 4W
Li WY 2013 CHF NA Internal Medicine 2008; NYHA 90 71 ± 4.6 73 ± 4.2 57.78 4W
Li XL 2013 CHF NA CMA 2007; NYHA 512 56.98 ± 11.59 57.53 ± 11.05 75.36 12W
Li YH 2013 CHF NA NYHA 80 67.3 ± 11.6 70 3M
Li YX 2012 diastolic heart failure in or out ESC criteria; MoH 2002 100 61.6 ± 5.1 61.4 ± 5.4 43 6M
Li YX 2013 CHF NA ESC 2007; MoH 2002;Collateral Disease Theory 2006 80 61.6 ± 5.1 61.4 ± 5.4 46.25 12M
Lin JH 2008 CHF in or out Clinical Cardiology 1999; NYHA 80 58 ± 12 60 4W
Lin ZJ 2010 heart failure derived from ischemic cardiomyopathy NA WHO/ISFC 1980; NYHA 60 40 ± 13 38 ± 12 45 6M
Liu HL 2008 CHF NA Guidelines for Cardiovascular Disease 2005; NYHA 86 32.9 ± 4.1 33.1 ± 3.2 52.33 4W
Liu J 2008 heart failure derived from ischemic cardiomyopathy NA WHO/ISFC 1980; NYHA 41 41 ± 11 40 ± 11 60.98 6M
Liu LX 2014 HF NA Practical Internal Medicine 2009 60 64.4 ± 11.5 64.5 ± 11.3 61.67 12W
Liu SJ 2009 CHF in or out Clinical Cardiology 1996; MoH 2002; NYHA 45 68.2 ± 7.6 66.8 ± 8.2 60 4W
Liu T 2013 HF NA NYHA 95 63.7 ± 7.4 65.7 ± 7.6 71.58 4W
Liu TR 2010 CHF NA NYHA 84 46-68 45-70 63.1 8W
Liu WJ 2007 ischemic cardiomyopathy in Felker's criteria 60 66 ± 10 65 ± 11 70 4M
Liu XC 2008 refractory heart failure NA NYHA 120 56-79 58-78 80.83 30D
Liu XC 2011 CHF in or out AHA criteria; NYHA 80 56.9 ± 7.3 57.0 ± 7.6 65 8W
Liu XG 2013 CHF in or out AHA criteria; NYHA; MoH 2002 60 61.2 ± 11.8 60.8 ± 12.5 58.33 3M
Liu XM 2010 HF NA ACC/AHA criteria; NYHA 76 65-82 52.63 3M
Liu XM 2013 CHF NA CMA 2007 64 69 ± 11 68 ± 12 57.81 4W
Liu YJ 2012 HF in or out Clinical Cardiology; NYHA 60 78-90 76-92 68.33 30D
Long F 2009 CHF in Clinical Cardiology 1996; CMA 2002; NYHA 110 20-73 18-70 53.64 4W
Lu JP 2012 CHF in CMA 2007; NYHA 60 73.2 ± 12.5 72.9 ± 11.8 65 24W
Luo Q 2013 chronic congestive heart failure in NYHA 60 62.5 ± 13.0 64.5 ± 12.2 56.67 3M
Ma AP 2013 CHF NA NYHA 96 66.28 ± 4.92 65.84 ± 5.06 56.25 6M
Ma FF 2008a CHF in Boston criteria 1985; NYHA 120 65.4 64.6 46.67 4W
Ma FF 2008b CHF in Boston criteria 1985; NYHA 65 64.1 ± 17.2 46.15 4W
Ma L 2010 CHF in or out ESC 1995; NYHA; MoH 2002 117 52.3 ± 9.2 50.1 ± 10.5 61.54 4W
Ma RX 2014 CHF in CMA 2007 120 62 ± 12 60 ± 11 65.75 4W
Miao S 2013 HF NA NYHA 102 77.2 ± 6.1 100 2M
Niu LY 2012 CHF NA ACC/AHA criteria; NYHA; MoH 2002 60 63.2 ± 4.1 60.8 ± 5.4 63.33 4W
Pang XM 2008 CHF NA Framingham criteria 31 66 ± 12 48.39 4W
Qiu X 2013 CHF NA NYHA 60 62 ± 4.2 60 ± 3.2 66.67 3M
Rao LZ 2012 CHF NA CMA 2007; NYHA 80 65 ± 15 64 ± 14 51.25 4W
Shen R 2010 HF in NYHA 62 74 ± 5 74 ± 7 77.42 28D
Shen XR 2014 CHF in or out ACC/AHA criteria; NYHA 122 62 ± 6 66.45 12M
Shi CP 2013 CHF in ISFC/WHO 1979; NYHA 120 64.5 ± 6.2 67.5 3M
Su HM 2007 chronic congestive heart failure in Framingham criteria; NYHA 1994 70 55.7 54.6 60 30D
Su LJ 2012 CHF in or out CMA 2002; Practical Internal Medicine 2001; NYHA 69 NA NA 65.22 8W
Su RY 2013 CHF NA CMA 2007; NYHA 86 69 46.51 4W
Sun LP 2007 chronic congestive heart failure in NYHA 60 62 ± 12 63.33 12W
Tang SY 2013 CHF in CMA 2002; Clinical Cardiology 1996; Internal Medicine 2004; NYHA 80 65.4 64.6 47.5 4W
Tao X 2011 CHF NA ESC 2008 100 NA NA 0 4W
Tian Y 2011 diastolic heart failure NA ESC criteria; MoH 2002 100 58.0 ± 8.2 58.0 ± 8.5 47 1M
Wang N 2014 CHF in or out MoH 2002 54 55-75 58-76 53.7 8W
Wang Q 2012 CHF in or out NYHA 80 40-70 41-70 61.25 24W
Wang SZ 2012 HF NA Diabetic Cardiomyopathy 2010; NYHA 60 60 ± 13 60 ± 11 61.67 4W
Wang YY 2013 chronic congestive heart failure in or out NYHA 79 62.6 ± 2.4 61.4 ± 2.3 53.16 4W
Wei XB 2013 CHF in NYHA; ACC/AHA 2009 84 87 ± 6 100 12W
Wen Y 2012 CHF NA CMA 2007; NYHA 90 70.4 ± 5.6 57.78 1M
Wu GL 2015 CHF out CMA 2007; NYHA 104 67.5 ± 6.8 66.7 ± 7.1 64.32 2M
Wu SP 2014 CHF in or out CMA 2014 130 52.2 ± 5.8 53.8 ± 7.3 73.8 4W
Wu Xian 2014 CHF in CMA 2007 60 64.47 ± 8.23 63.57 ± 8.94 55.38 4W
Xiong SQ 2014 CHF in CMA 2007; NYHA 80 61.2 ± 7.11 62.3 ± 7.45 52.5 6W
Xu GS 2014 CHF NA NYHA 64 55.7 ± 14.0 53.6 ± 15.0 59.38 120D
Xue L 2014 CHF in A list of clinical manifestation 124 42-86 64.52 8W
Xue LX 2008 chronic congestive heart failure in or out AHA criteria 80 56.9 ± 7.3 57.0 ± 7.6 65 8W
Yan KL 2012 CHF in Practical Internal Medicine 2009; NYHA 120 65.2 ± 17.5 56.67 12W
Yang DK 2014 CHF in NYHA 60 66.0 ± 12.06 65.8 ± 11.33 63.33 4W
Yang F 2007 CHF NA ESC 2005 128 66.0 ± 14.0 65.0 ± 15.0 56.25 8W
Yang HT 2012 CHF in Clinical Cardiology 1999; NYHA 100 58.5 ± 7.0 59 ± 7.6 57 4W
Yang HT 2013 CHF in Clinical Cardiology 1999 100 58.5 ± 7.0 59 ± 7.6 57 4W
Yang J 2013 CHF NA CMA 2007; NYHA 90 56.8 ± 4.3 C1 (57.2 ± 4.1) C2 (57.1 ± 3.9) 43.33 12W
Yang W 2012 CHF in CMA 2007; NYHA 80 60.52 ± 12.6 62.7 ± 9.6 56.25 4W
Yao L 2011 CHF in CMA 2007; NYHA 102 52 ± 11 56 ± 9 52.94 8W
Ye RS 2013 CHF NA CMA 2007; NYHA 80 65-92 65-90 56.25 6M
Ye S 2012 CHF in CMA 2007; NYHA 114 60.29 ± 5.62 53.51 3M
Yin ZL 2009 congestive heart failure in Framingham criteria; NYHA 50 57.4 ± 7.6 66 4W
Ying M 2013 CHF NA Framingham criteria; NYHA 80 50-80 52.5 3M
Yu JH 2008 diastolic heart failure in Framingham criteria; CHFA 2001; NYHA 70 65.7 ± 6.1 66.1 ± 8.2 60 12M
Yuan JK 2012 HF in NYHA 62 41.65 ± 9.33 43.08 ± 7.55 58.06 4W
Zhai N 2015 CHF NA CMA 2014 80 70.6 ± 4.4 61.54 12W
Zhang CA 2013 CHF in or out AHA 1995; NYHA 83 59.31 ± 10.19 61.0 ± 8.39 66.27 12W
Zhang H 2011 CHF NA ISFC/WHO criteria 123 45-80 50-82 60.16 4W
Zhang J 2015 CHF NA Practical Internal Medicine 1998,NYHA 60 63.1 ± 9.5 62.5 ± 8.2 50 4W
Zhang R 2014 CHF in CMA 2007; NYHA 80 55.0 ± 10.9 53.0 ± 11.3 62.14 8W
Zhang WL 2013 CHF in NYHA 94 47-86 45-87 58.51 4W
Zhang XX 2010 left cardiac insufficiency NA NYHA 136 53.5 52.94 6M
Zhao JS 2014 CHF NA CMA 2007; NYHA; MoH 2002 450 54.8 ± 4.6 55.3 ± 4.7 48.33 12W
Zhao MJ 2009 &Zhao MJ 2012 HF in or out Framingham criteria; NYHA 68 46-69 45-69 64.71 4W
Zheng JJ 2012 CHF in CMA 2007; NYHA 76 64 ± 15 64 ± 14 55.26 6M
Zheng LW 2013 CHF in or out CMA 2007; NYHA 164 66.9 ± 11.5 67.8 ± 12.0 53.05 12W
Zheng WH 2014 refractory heart failure NA NYHA 87 63.44 ± 2.20 61.92 ± 2.70 56.32 6W
Zhou FZ 2011a congestive heart failure in NYHA 59 66 69.49 12W
Zhou Y 2013 HF NA Internal Medicine 2010 60 56.9 ± 7.3 57.0 ± 7.6 63.33 8W
Zhu HG 2012 CHF in or out NYHA 78 63.1 63.4 61.54 3M
Zhuo JY 2013 CHF NA NYHA 136 62.74 ± 7.78 61.01 ± 8.12 54.41 4W
  1. ACC American College of Cardiology, AHA American Heart Association, C control group, CHF chronic heart failure, CHFA Chinese Heart Failure Association, CMA Chinese Medical Association, ESC European Society of Cardiology, HF heart failure, ISFC International Society and Federation of Cardiology, ISH International Society of Hypertension, MoH Ministry of Health in China, NA not available, NYHA New York Heart Association, T treatment group, WHO World Health Organization