Skip to main content

Table 4 MIC of antibiotics after the association of resveratrol (4) at MIC/2 and MIC/4 against selected MDR bacteria

From: Antibacterial and antibiotic-resistance modifying activity of the extracts and compounds from Nauclea pobeguinii against Gram-negative multi-drug resistant phenotypes

Antibioticsa

Concentration of 4

Bacteria strainsb, MIC of antibiotics alone and in presence of 4 (Resveratrol), FIC (in bracket )

PBSS (%)c

PA124

CM64

KP55

AG102

AG100Atet

PS2636

 

CHL

0

256

128

32

64

64

256

 
 

MIC/2

32 (0.25)S

2(0.02)S

16(0.5)S

64(1)I

<2(<0.03)S

64(0.25)S

5/6 (83.3 %)

 

MIC/4

32(0.25)S

4(0.03)S

16(0.5)S

64(1)I

<2 (<0.03)S

64(0.25)S

5/6(83.3 %)

KAN

0

128

64

64

4

32

4

 
 

MIC/2

64(0.5)S

<2 (<0.03)S

32(0.5)S

<2 (<0.5)S

<2(0.06)S

4(1)I

5/6(83.3 %)

 

MIC/4

64(0.5)S

<2 (<0.03)S

32(0.5)S

<2 (<0.5)S

<2(0.06)S

4(1)I

5/6(83.3 %)

STR

0

64

128

64

≤2

−

≤2

 
 

MIC/2

32(0.5)S

64(0.5)S

16(0.25)S

<2 na

64(≤0.5)S

<2 na

4/4 (100 %)

 

MIC/4

32(0.5)S

64(0.5)S

32(0.5)S

4(>2) na

128(≤0.5)S

<2 na

4/4 (100 %)

CIP

0

64

8

4

1

64

4

 
 

MIC/2

4(0.06)S

<2(0.25)S

<2(<0.5)S

<0.5(<0.5)S

<2(<0.03)S

8(2)I

5/6(83.3 %)

 

MIC/4

16(0.25)S

<2(0.25)S

<2(<0.5)S

<0.5(<0.5)S

<2(<0.03)S

<0.5(<0.13)S

6/6 (100 %)

TET

0

64

64

32

4

256

64

 
 

MIC/2

4(0.06)S

64(1)I

32(1)I

<2(<0.5)S

256(1)I

32(0.5)S

3/6 (50 %)

 

MIC/4

4(0.06)S

128(2)I

16(0.5)S

<2(<0.5)S

256(1)I

16(0.25)S

4/6 (66.7 %)

  1. (−): >256 μg/mL; 0: without compound 4 (only antibiotic tested). CIP have been tested at 64 μg/ml on AG102 and PS2636; na: non-applicable; Values in bold: MIC of antibiotic alone or significant synergistic effects
  2. S Synergy, I Indifference, A Antagonism, P product, FIC fractional inhibitory concentration
  3. aAntibiotics [CHL: chloramphenicol, KAN : kanamycin, STR: streptomycin, CIP : ciprofloxacin, TET : tetracycline]
  4. bBacterial strains: Escherichia coli [ AG102, AG100Atet], Pseudomonas aeruginosa [PA124], Enterobacter aerogenes [CM64], Klebsiella pneumoniae [KP55], Providencia stuartii [PS2636]
  5. cPBSS: percentage of bacteria strain on which synergism has been observed