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Table 3 IC50 values of plant extracts/fractions and isolated compounds against tumor cell lines

From: Cytotoxic potential of selected medicinal plants in northeast Brazil

No. Plant species Parts of planta (Extractionsb) Cellsc (IC50 in μg/mL)d
B16-F10 HepG2 HL60 K562 PBMC
04 Byrsonima sericea DC. L (m/e) 13.46 27.95 32.56 >50 33.81
10.47–17.30 20.79–37.60 25.44–41.66 26.45–43.23
05 L (ea/e) 17.44 41.53 28.21 >50 >50
13.95–21.81 35.31–48.85 21.18–37.57
07 L (h/e) 16.89 26.19 16.14 28.32 17.58
14.63–19.49 23.14–29.64 13.85–18.82 16.96–47.29 10.01–30.86
11 Duranta repens Linn. L (c/e) 29.00 33.78 22.41 21.12 >50
24.51–34.30 29.44–38.75 14.10–35.62 17.77–25.11
56 Quercetin - 12.12 12.15 8.81 14.93 14.39
9.92–14.81 9.82–15.05 7.28–10.65 13.90–16.04 11.18–18.52
19 Himatanthus bracteatus (A.DC.) Woodson L (c/e) 22.43 24.75 23.06 29.85 12.53
20.80–24.18 21.70–28.22 20.62–25.79 26.87–33.15 8.28–18.96
20 Ipomoea purga (Wender.) Hayne S (e) 7.39 8.52 9.39 8.53 6.99
6.03–9.07 7.51–9.65 7.81–11.30 7.61–9.56 4.43–11.02
21 L (e) 16.30 29.63 32.64 28.95 30.71
11.80–22.51 25.59–34.31 28.15–37.85 24.39–34.36 24.04–39.24
28 Ixora coccinea Linn. F (c/e) 40.41 38.25 36.92 >50 >50
36.60–44.63 30.46–48.04 33.52–40.67
57 Mixture of α- and β-amyrin - 23.21 24.09 >25 >25 Nd
18.51–29.11 18.71–31.01
29 Mabea piriri Aubl. S (e) 17.76 32.98 22.72 21.89 >50
13.42–23.51 27.61–39.40 13.26–38.91 15.52–30.87
37 Ocotea longifolia Kunth (Oreodaphne opifera Mart. Nees) L (e) 37.07 37.34 31.00 43.34 21.06
32.10–42.81 31.34–44.49 21.04–45.69 39.47–47.58 17.48–25.37
43 Psychotria capitata Ruiz & Pav. L (ea/e) 15.58 18.32 18.91 31.38 12.73
11.29–21.51 14.91–22.50 13.93–25.67 22.78–43.22 7.43–21.81
44 L (c/e) 27.06 37.06 36.06 16.45 29.14
19.26–38.02 31.54–43.53 28.65–45.40 13.16–20.56 22.46–37.82
  Doxorubicine   0.08 0.03 0.02 0.06 0.14
0.06–0.11 0.02–0.03 0.02–0.02 0.04–0.09 0.02–1.08
  1. Nd Not determined
  2. aParts of the plant: L leaves, S stem, and F Fruits
  3. bExtractions: h hexane, m methanol, e ethanol, m/e methanol/H2O partition from the ethanolic extract, ea/e ethyl acetate partition from the ethanolic extract, h/e hexane partition from the ethanolic extract, c/e chloroform partition from the ethanolic extract, h:ea/e hexane:ethyl acetate (1:1) partition from the ethanolic extract
  4. cTumor cells: B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), HL-60 (human promyelocytic leukemia) and K562 (human chronic myelocytic leukemia). Non-tumor cells: PBMC (human peripheral blood mononuclear cells activated with concanavalin A – human lymphoblast)
  5. dData are presented as IC50 values in μg/mL and their 95 % confidence interval obtained by nonlinear regression from three independent experiments performed in duplicate, measured using alamar blue assay after 72 h incubation. The negative control received the vehicle used to dilute the tested samples (0.5 % DMSO)
  6. eDoxorubicin was used as the positive control
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