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Table 2 Growth inhibitory effects of plant extracts/fractions against tumor cell lines

From: Cytotoxic potential of selected medicinal plants in northeast Brazil

No.

Plant species

Parts of the planta (Extractionsb)

Cellc growth inhibition percentage (GI %)d

HepG2

HL60

01

Byrsonima sericea DC.

F (e)

25.03 ± 5.24

25.27 ± 8.79

02

S (e)

8.02 ± 6.85

27.32 ± 0.06

03

L (e)

21.84 ± 2.64

64.71 ± 5.28

04

L (m/e)

91.16 ± 0.64

102.7 ± 1.12

05

L (ea/e)

92.14 ± 0.64

103.3 ± 7.26

06

L (c/e)

39.96 ± 9.49

70.12 ± 11.24

07

L (h/e)

91.62 ± 0.39

109.0 ± 2.52

08

Cupania impressinervia Acev. Rodr. var. (revoluta) Radlk

L (e)

23.10 ± 5.59

55.19 ± 5.50

09

Duranta repens Linn.

FL (m/e)

14.09 ± 7.14

33.3 ± 0.92

10

FL (ea/e)

20.57 ± 7.67

28.36 ± 0.46

11

FL (c/e)

79.94 ± 2.97

98.67 ± 6.35

12

Helicostylis tomentosa (Poepp. & Endl) Rusby

S (e)

14.55 ± 3.30

53.67 ± 0,58

13

L (e)

7.96 ± 3.56

38.39 ± 7.33

14

Himatanthus bracteatus (A.DC.) Woodson

S (e)

20.55 ± 1.61

29.38 ± 1.63

15

L (e)

−9.90 ± 6.56

−16.91 ± 4.61

16

L (h)

14.78 ± 5.22

70.63 ± 2.62

17

L (m/e)

−0.77 ± 2.61

28.55 ± 3.25

18

L (ea/e)

5.70 ± 2.61

56.16 ± 9.49

19

L (c/e)

92.30 ± 1.50

93.63 ± 0.30

20

Ipomoea purga (Wender.) Hayne

S (e)

98.39 ± 1.81

95.58 ± 1.33

21

L (e)

93.86 ± 2.70

106.4 ± 3.62

22

Ixora coccinea Linn.

F (e)

−2.97 ± 9.22

1.27 ± 3.86

23

FL (h)

21.47 ± 5.44

−25.64 ± 9.33

24

L (m/e)

9.25 ± 4.73

1.38 ± 1.35

25

L (ea/e)

7.49 ± 5.16

32.25 ± 9.39

26

L (h/e)

22.55 ± 3.23

58.78 ± 1.34

27

F (ea/e)

−5.53 ± 7.07

18.83 ± 5.74

28

F (c/e)

94.93 ± 0.74

92.97 ± 2.39

29

Mabea piriri Aubl.

S (e)

81.41 ± 8.27

92.35 ± 7.66

30

L (e)

12.48 ± 5.12

69.56 ± 0.17

31

Miconia minutiflora

S (e)

25.64 ± 6.34

38.17 ± 1.16

32

L (e)

38.62 ± 2.72

66.54 ± 0.85

33

Momordica charantia L.

L (e)

−17.51 ± 2.97

9.30 ± 5.64

34

Ocotea glomerata (Nees) Mez

S (e)

49.49 ± 9.87

32.70 ± 9.32

35

L (c/e)

25.48 ± 7.87

52.0 ± 3.12

36

Ocotea longifolia Kunth (Oreodaphne opifera Mart. Nees)

S (e)

−7.43 ± 5.88

2.49 ± 0.33

37

L (e)

93.88 ± 2.12

94.70 ± 1.06

38

Pavonia fruticosa (Mill.) Fawc. & Rendle

S (e)

44.81 ± 1.66

41.65 ± 6.51

39

L (e)

33.34 ± 4.48

55.82 ± 4.66

40

Psychotria capitata Ruiz & Pav.

S (e)

15.82 ± 3.12

64.16 ± 0.32

41

L (e)

28.13 ± 8.45

22.00 ± 5.92

42

L (m/e)

19.16 ± 8.90

51.72 ± 4.86

43

L (ea/e)

95.14 ± 1.83

86.55 ± 4.20

44

L (c/e)

96.92 ± 1.68

92.87 ± 0.06

45

L (h/e)

12.28 ± 4.71

−26.37 ± 1.89

46

L (h:ea/e)

61.84 ± 9.74

48.62 ± 1.18

47

Schefflera morototoni (Aubl.) Maguire, Steyerm. & Frodin

S (e)

42.73 ± 1.59

−23.89 ± 3.53

48

L (e)

9.05 ± 7.07

63.74 ± 8.13

49

Solanum paludosum Moric.

S (e)

17.69 ± 5.22

63.81 ± 2.08

50

Xylopia frutescens Aubl.

S (e)

19.36 ± 3.74

72.39 ± 2.90

51

L (m/e)

29.88 ± 2.90

18.19 ± 6.52

52

L (ea/e)

19.46 ± 7.46

51.24 ± 5.86

53

L (c/e)

71.00 ± 3.06

62.71 ± 4.30

54

L (h/e)

23.49 ± 3.57

69.41 ± 0.88

55

Zanthoxylum rhoifolium Lam.

L (e)

15.53 ± 5.03

14.00 ± 4.00

 

Doxorubicine

 

85.20 ± 0.78

86.34 ± 2.27

  1. aParts of the plant: L leaves, S stem, F Fruits, FL flowers
  2. bExtractions: h hexane, m methanol, e ethanol, m/e methanol/water partition from the ethanolic extract, ea/e ethyl acetate partition from the ethanolic extract, h/e hexane partition from the ethanolic extract, c/e chloroform partition from the ethanolic extract, h:ea/e, hexane:ethyl acetate (1:1) partition from the ethanolic extract
  3. cCell lines: HepG2 (human hepatocellular carcinoma) and HL60 (human promyelocytic leukemia)
  4. dGI % values are presented as the mean ± S.E.M. of two independents experiment performed in triplicate measured by the alamar blue assay after 72 h incubation. All extracts were tested at a concentration of 50 μg/mL. The negative control received the vehicle used to dilute the tested samples (0.5 % DMSO)
  5. eDoxorubicin was used as the positive control