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Table 2 Growth inhibitory effects of plant extracts/fractions against tumor cell lines

From: Cytotoxic potential of selected medicinal plants in northeast Brazil

No. Plant species Parts of the planta (Extractionsb) Cellc growth inhibition percentage (GI %)d
HepG2 HL60
01 Byrsonima sericea DC. F (e) 25.03 ± 5.24 25.27 ± 8.79
02 S (e) 8.02 ± 6.85 27.32 ± 0.06
03 L (e) 21.84 ± 2.64 64.71 ± 5.28
04 L (m/e) 91.16 ± 0.64 102.7 ± 1.12
05 L (ea/e) 92.14 ± 0.64 103.3 ± 7.26
06 L (c/e) 39.96 ± 9.49 70.12 ± 11.24
07 L (h/e) 91.62 ± 0.39 109.0 ± 2.52
08 Cupania impressinervia Acev. Rodr. var. (revoluta) Radlk L (e) 23.10 ± 5.59 55.19 ± 5.50
09 Duranta repens Linn. FL (m/e) 14.09 ± 7.14 33.3 ± 0.92
10 FL (ea/e) 20.57 ± 7.67 28.36 ± 0.46
11 FL (c/e) 79.94 ± 2.97 98.67 ± 6.35
12 Helicostylis tomentosa (Poepp. & Endl) Rusby S (e) 14.55 ± 3.30 53.67 ± 0,58
13 L (e) 7.96 ± 3.56 38.39 ± 7.33
14 Himatanthus bracteatus (A.DC.) Woodson S (e) 20.55 ± 1.61 29.38 ± 1.63
15 L (e) −9.90 ± 6.56 −16.91 ± 4.61
16 L (h) 14.78 ± 5.22 70.63 ± 2.62
17 L (m/e) −0.77 ± 2.61 28.55 ± 3.25
18 L (ea/e) 5.70 ± 2.61 56.16 ± 9.49
19 L (c/e) 92.30 ± 1.50 93.63 ± 0.30
20 Ipomoea purga (Wender.) Hayne S (e) 98.39 ± 1.81 95.58 ± 1.33
21 L (e) 93.86 ± 2.70 106.4 ± 3.62
22 Ixora coccinea Linn. F (e) −2.97 ± 9.22 1.27 ± 3.86
23 FL (h) 21.47 ± 5.44 −25.64 ± 9.33
24 L (m/e) 9.25 ± 4.73 1.38 ± 1.35
25 L (ea/e) 7.49 ± 5.16 32.25 ± 9.39
26 L (h/e) 22.55 ± 3.23 58.78 ± 1.34
27 F (ea/e) −5.53 ± 7.07 18.83 ± 5.74
28 F (c/e) 94.93 ± 0.74 92.97 ± 2.39
29 Mabea piriri Aubl. S (e) 81.41 ± 8.27 92.35 ± 7.66
30 L (e) 12.48 ± 5.12 69.56 ± 0.17
31 Miconia minutiflora S (e) 25.64 ± 6.34 38.17 ± 1.16
32 L (e) 38.62 ± 2.72 66.54 ± 0.85
33 Momordica charantia L. L (e) −17.51 ± 2.97 9.30 ± 5.64
34 Ocotea glomerata (Nees) Mez S (e) 49.49 ± 9.87 32.70 ± 9.32
35 L (c/e) 25.48 ± 7.87 52.0 ± 3.12
36 Ocotea longifolia Kunth (Oreodaphne opifera Mart. Nees) S (e) −7.43 ± 5.88 2.49 ± 0.33
37 L (e) 93.88 ± 2.12 94.70 ± 1.06
38 Pavonia fruticosa (Mill.) Fawc. & Rendle S (e) 44.81 ± 1.66 41.65 ± 6.51
39 L (e) 33.34 ± 4.48 55.82 ± 4.66
40 Psychotria capitata Ruiz & Pav. S (e) 15.82 ± 3.12 64.16 ± 0.32
41 L (e) 28.13 ± 8.45 22.00 ± 5.92
42 L (m/e) 19.16 ± 8.90 51.72 ± 4.86
43 L (ea/e) 95.14 ± 1.83 86.55 ± 4.20
44 L (c/e) 96.92 ± 1.68 92.87 ± 0.06
45 L (h/e) 12.28 ± 4.71 −26.37 ± 1.89
46 L (h:ea/e) 61.84 ± 9.74 48.62 ± 1.18
47 Schefflera morototoni (Aubl.) Maguire, Steyerm. & Frodin S (e) 42.73 ± 1.59 −23.89 ± 3.53
48 L (e) 9.05 ± 7.07 63.74 ± 8.13
49 Solanum paludosum Moric. S (e) 17.69 ± 5.22 63.81 ± 2.08
50 Xylopia frutescens Aubl. S (e) 19.36 ± 3.74 72.39 ± 2.90
51 L (m/e) 29.88 ± 2.90 18.19 ± 6.52
52 L (ea/e) 19.46 ± 7.46 51.24 ± 5.86
53 L (c/e) 71.00 ± 3.06 62.71 ± 4.30
54 L (h/e) 23.49 ± 3.57 69.41 ± 0.88
55 Zanthoxylum rhoifolium Lam. L (e) 15.53 ± 5.03 14.00 ± 4.00
  Doxorubicine   85.20 ± 0.78 86.34 ± 2.27
  1. aParts of the plant: L leaves, S stem, F Fruits, FL flowers
  2. bExtractions: h hexane, m methanol, e ethanol, m/e methanol/water partition from the ethanolic extract, ea/e ethyl acetate partition from the ethanolic extract, h/e hexane partition from the ethanolic extract, c/e chloroform partition from the ethanolic extract, h:ea/e, hexane:ethyl acetate (1:1) partition from the ethanolic extract
  3. cCell lines: HepG2 (human hepatocellular carcinoma) and HL60 (human promyelocytic leukemia)
  4. dGI % values are presented as the mean ± S.E.M. of two independents experiment performed in triplicate measured by the alamar blue assay after 72 h incubation. All extracts were tested at a concentration of 50 μg/mL. The negative control received the vehicle used to dilute the tested samples (0.5 % DMSO)
  5. eDoxorubicin was used as the positive control