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Fig. 4 | BMC Complementary and Alternative Medicine

Fig. 4

From: Herbal formula GAPT prevents beta amyloid deposition induced Ca2+/Calmodulin-dependent protein kinase II and Ca2+/Calmodulin-dependent protein phosphatase 2B imbalance in APPV717I mice

Fig. 4

Expression of CaMKII (Average OD) in hippocampal CA1 region in the experimental mice at the age of 11 months old were measured by immunohistochemistry staining. Notes: p < 0.05, ▲▲ p < 0.01,vs control group, *p < 0.05, **p < 0.01,vs model group, ANOVA. Control: C57BL/6 J mice; APP: APPV717I mice; APP + D: donepezil; APP + Gl: GAPT low dose; APP + Gm: GAPT middle dose; APP + Gh: GAPT high dose. CaMKII expression was determined by immunohistochemistry in the hippocampus of experimental mice. Data are expressed as mean ± SD (Average OD) of the CaMKII positive neuronal area (anti-body for CaMKII, 1:1000)

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