Fig. 4
From: Suppression of neuropeptide production by quercetin in allergic rhinitis model rats
Influence of quercetin on the appearance of substance P (SP) in nasal lavage fluids after toluene 2,4-diisocyanate (TDI) nasal instillation in sensitized rats. TDI-sensitized rats were treated with various doses of quercetin for 5 days before TDI provocation. Olopatadine hydrochloride (OH) was administered orally into TDI-sensitized rats once a day for 5 days at a single dose of 10 mg/kg before the provocation. The levels of SP in nasal lavage fluids obtained from sensitized rats 6 h after TDI nasal challenge were measured by ELISA. The data are expressed as the mean pg/ng IgA ± standard errors of the means of five rats/group. NC: non-sensitized, non-treated control; EA: ethyl acetate