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Table 1 In vitro antitrypanosomal activity of the most active plant extracts against Trypanosoma brucei

From: Screening North American plant extracts in vitro against Trypanosoma brucei for discovery of new antitrypanosomal drug leads

NPID Sample name Family Common name Plant part IC50 (μg/mL) IC90 (μg/mL)
81880 Alnus rubra Betulaceae Red alder BK 0.94 ± 0.58 1.95 ± 0.17
81890 Boykinia major Saxifragaceae Large Boykinia RT 2.82 ± 0.44 8.31 ± 1.50
81897 Juniperus communis Cupressaceae Juniper LF-ST 2.40 ± 0.44 6.66 ± 2.13
81908 Chrysolepis chrysophylla Fagaceae Golden chinquapin FL 2.89 ± 0.40 7.31 ± 1.57
81925 Rhododendron occidentale Ericaceae Western azalea LF 2.87 ± 0.43 6.88 ± 1.16
81940 Arctostaphylos viscida Ericaceae Whiteleaf manzanita, sticky manzanita LF 2.88 ± 0.21 5.96 ± 1.09
81953 Eriogonum umbellatum Polygonaceae Buckwheat LF-ST 2.79 ± 0.34 6.25 ± 1.94
82438 Eriogonum fisciculatum Polygonaceae California or Eastern Mojave buckwheat LF 2.68 ± 0.44 7.73 ± 2.33
82440 Rhus integrifolia Anacardiaceae Lemonade berry LF 2.97 ± 0.01 4.41 ± 0.29
82453 Hoita macrostachya Fabaceae Large leatherroot LF 0.48 ± 0.00 0.62 ± 0.00
82466 Lepechinia calycina Lamiaceae Pitcher sage; woodbalm LF 2.50 ± 0.05 5.04 ± 0.12
82467 Ribes speciosum Grossulariaceae Fuchsia-flowered gooseberry LF-ST-FL 2.95 ± 0.10 5.90 ± 0.08
82468 Salvia spathacea Lamiaceae Pitcher or hummingbird sage ST 1.13 ± 0.78 3.46 ± 0.34
82484 Sabal minor Arecaceae Bush palmetto FL 1.06 ± 0.44 2.07 ± 0.96
83334 Medinilla magnifica Melastomataceae Chandelier tree FL-FR 2.25 ± 1.16 7.89 ± 2.48
83345 Eucalyptus citriodora Myrtaceae Lemon-scented gum LF 2.91 ± 0.21 5.82 ± 0.04
83360 Acer rubrum Sapindaceae Red maple LF 2.88 ± 0.50 7.45 ± 0.70
84470 Ligustrum sinense Oleaceae Privet LF-FR 2.77 ± 0.40 4.41 ± 1.46
84516 Hamamelis virginiana Hamamelidaceae Witch hazel ST 2.54 ± 0.53 4.65 ± 3.92
84686 Lyonia fruticosa Ericaceae Coastal plain staggerbush ST 2.54 ± 0.71 4.65 ± 3.92
84709 Ribes montigenum Grossulariaceae Gooseberry-currant ST 1.94 ± 0.67 7.39 ± 2.74
84712 Quercus alba Fagaceae White oak BK 1.42 ± 0.30 7.53 ± 0.44
84715 Leea rubra Vitaceae West Indian holly, red leea ST 1.62 ± 0.32 4.50 ± 1.04
84720 Coccoloba pubescens Polygonaceae Grandleaf seagrape ST 0.83 ± 0.04 1.91 ± 0.16
84722 Rhus integrifolia Anacardiaceae Lemonade berry ST 0.50 ± 0.10 1.07 ± 0.33
84738 Nuphar luteum Nymphaeaceae Water lilly FR 0.42 ± 0.02 1.32 ± 0.11
131665 Difluoromethylornithine     5.07 ± 0.27 12.37 ± 0.96
103650 Pentamidine     0.002 ± 0.001 0.003 ± 0.001
  1. (A complete list of plants screened is presented as supplement material –Additional file 1: Table S1 and Table S2) NPID- Natural Product Identification Details (accession number); Plant parts- BK- stem bark; LF- leaves; FL- flowers; ST- stem; FR- fruit; IC50 and IC90 values are mean ± SD