Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. in normoglycaemic and streptozotocin-induced diabetic rats

Table 2 Effect of GME on kidney profiles, SGOT, SGPT, ALP, and total protein in STZ-treated diabetic rats

Experimental group	SGOT (U/L)	SGPT (U/L)	ALP (U/L)	Urea (mg/dL)	Creatinine (mg/dL)	TP (g/dL)
Normal control	22.5 ± 2.46	64.5 ± 6.25	74.78 ± 5.40	22.5 ± 2.07	0.81 ± 0.03	7.12 ± 0.15
Diabetic control	76 ± 5.73^*	159.5 ± 7.08^*	173.5 ± 15.51^*	143.7 ± 7.57^*	1.25 ± 0.13^*	5.05 ± 0.24^*
STZ + 0.5 mg/kg glibenclamide	38.17 ± 3.62^**	66.83 ± 5.46^**	147.83 ± 15.90	54.25 ± 3.46^**	0.99 ± 0.04	7.85 ± 0.24^**
STZ + 50 mg/kg GME	87.5 ± 12.46	137.83 ± 6.28	156.67 ± 13.19	135.3 ± 3.86	0.84 ± 0.07^**	6.15 ± 0.26^**
STZ + 100 mg/kg GME	52 ± 3.91^**	125.33 ± 6.86^**	149.5 ± 11.84	96.6 ± 2.28^**	0.98 ± 0.07	6.75 ± 0.13^**
STZ + 200 mg/kg GME	56.17 ± 5.43^**	148.5 ± 12.16	157.83 ± 14.91	105.77 ± 4.05^**	0.87 ± 0.041^**	6.72 ± 0.14^**

^*significantly different (p < 0.05) when compared to the normal control group of the respective column
^** significantly different (p < 0.05) when compared to the diabetic control group of the respective column
Data are expressed as mean ± S.E.M. for six separate observations (n = 6); One-way ANOVA test followed by Tukey’s post-hoc test (p < 0.05) was used to analyse differences among the selected kidney’s profiles

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