Hypoglycaemic activity of ethanolic extract of Garcinia mangostana Linn. in normoglycaemic and streptozotocin-induced diabetic rats

Table 1 Effect of GME at various doses on the serum lipid profiles in STZ-treated diabetic rats

Experimental group	TG (mg/dL)	TC (mg/dL)	HDL (mg/dL)	LDL (mg/dL)	VLDL (mg/dL)
Normal control	85.00 ± 3.20	73.83 ± 4.35	15.50 ± 0.57	41.34 ± 4.45	17.00 ± 0.64
Diabetic control	219.5 ± 7.66^*	133.5 ± 3.15^*	11.46 ± 1.31	78.14 ± 4.61^*	43.9 ± 1.53^*
STZ + 0.5 mg/kg glibenclamide	104.17 ± 3.48^**	71 ± 3.53^**	20.26 ± 1.23^**	29.91 ± 4.00^**	20.83 ± 0.70^**
STZ + 50 mg/kg GME	159.67 ± 5.23^**	92 ± 2.32^**	13.42 ± 1.28	46.65 ± 3.47^**	31.93 ± 1.05^**
STZ + 100 mg/kg GME	131.67 ± 5.37^**	91.5 ± 2.17^**	12.92 ± 1.02	52.25 ± 2.20^**	26.33 ± 1.07^**
STZ + 200 mg/kg GME	133.17 ± 3.40^**	73.67 ± 4.06^**	15.5 ± 1.20	31.53 ± 4.34^**	26.63 ± 0.68^**

^*significantly different (p < 0.05) when compared to the normal control group of the respective column
^** significantly different (p < 0.05) when compared to the diabetic control group of the respective column
Data are expressed as mean ± S.E.M. for six separate observations (n = 6); One-way ANOVA test followed by Tukey’s post-hoc test (p < 0.05) was used to analyse differences among the selected lipid profiles

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