From: A mechanistic approach to anti-nociceptive potential of Artemisia macrocephala Jacquem
Treatment/dose | Time in sec (tail flick)/response (%) | |||||
---|---|---|---|---|---|---|
15 min | 30 min | 45 min | 60 min | 75 min | 90 min | |
Control (2 % Tween 80) | 0.79±0.035 | 0.89±0.025 | 0.97±0.027 | 0.94±0.036 | 0.87±0.027 | 0.93±0.045 |
Crd 150 mg 300 mg | 0.97±0.130 (18.55 %) | 1.24±0.124* (28.22 %) | 1.69±0.139 (42.60 %) | 2.10±0.122** (55.23 %) | 2.34±0.134** (62.82 %) | 2.05±0.124** (54.63 %) |
1.09±0.130* (27.52 %) | 1.40±0.121* (36.42 %) | 1.92±0.129** (49.47 %) | 2.77±0.130** (66.06 %) | 3.18±0.165*** (72.64 %) | 3.03±0.140*** (69.30 %) | |
Chf 100 mg 200 mg | 1.10±0.995* (28.18 %) | 1.35±0.399* (34.07 %) | 1.98±0.236** (51.01 %) | 3.37±0.220** (72.10 %) | 3.75±0.213*** (76.80 %) | 3.31±0.237*** (71.90 %) |
1.16±0.029* (31.89 %) | 1.41±0.021* (36.87 %) | 2.10±0.042** (53.80 %) | 5.29±0.060** (82.23 %) | 4.33±0.041*** (79.90 %) | 4.47±0.057*** (79.19 %) | |
EtOA 100 mg 200 mg | 1.04±0.214* (24.03 %) | 1.29±0.241* (31.00 %) | 1.87±0.361** (48.12 %) | 3.10±0.421** (69.67 %) | 3.38±0.302** (74.26 %) | 2.76±0.280*** (66.30 %) |
1.10±0.201* (28.18 %) | 1.33±0.202* (33.08 %) | 1.91±0.350** (49.21 %) | 3.19±0.435** (70.53 %) | 3.30±0.313*** (73.63 %) | 2.79±0.291*** (66.66 %) | |
Standard (Morphine 5 mg) | 1.52 ±0.024 (48.02 %) | 2.03 ±0.066 (56.15 %) | 3.89±0.038 (75.06 %) | 6.30±0.054 (85.07 %) | 4.40±0.050 (80.22 %) | 4.30±0.074 (78.37 %) |
N +Crd 150 mg 300 mg | 0.79±0 .1 0 8 | 0 .95±0 .044 | 0 . 99±0.045 | 0.99±0.064 | 0.95±0.026 | 0.81±0.042 |
0.84±0.046 | 0.98±0.031 | 1.14±0.047 | 0.99±0.035 | 0.96±0.051 | 0.92±0.034 | |
N +Chf 100 mg 200 mg | 0.93±0.048 | 0.92±0.036 | 1.10±0.031 | 1.10±0.047 | 0.90±0.038 | 0.93±0.061 |
0.87±0.037 | 0.91±0.065 | 1.50±0.049 | 0.99±0.038 | 0.89±0.029 | 0.95±0.044 | |
N +EtOA 100 mg 200 mg | 0 . 89±0.03 3 | 0 .93±0 .0 5 1 | 1.20±0.051 | 1.11±0.034 | 0.91±0.061 | 0.90±0.056 |
0.85±0.037 | 0.90±0.065 | 0.99±0.049 | 1.12±0.038 | 0.91±0.029 | 0.99±0.044 | |
Morphine (5 mg) + Naloxone (2 mg) | 0.77±0.022 | 0.87±0.036 | 0.94±0.040 | 0.91±0.034 | 0.91±0.030 | 0.91±0.042 |