A mechanistic approach to anti-nociceptive potential of Artemisia macrocephala Jacquem

Table 2 To show effects of Artemisia macrocephala on formalin-induced paw-licking response

Treatment/dose		Licking	Time (sec)	Inhibition (%)
Treatment/dose		1st phase	2nd phase	1st phase	2nd phase
Control (2 % Tween 80)		50.03 ± 1.63	72.00 ± 1.30	----
Crd	150 mg	34.22±1.12**	37.25±1.619**	31.60	48.26
	300 mg	31.05±1.125**	31.05±1.668***	37.93	56.87
Chf	100 mg	28.25±1.65**	30.50±1.425**	43.53	57.63
	200 mg	24.34±1.411***	19.05±1.039***	51.34	73.54
EtOA	100 mg	28.96±1.55**	30.95±1.441***	42.11	57.01
	200 mg	27.35 ±1.05**	24.02 ±0.95**	45.33	66.63
Indomethacin (10 mg)		39.83±1.55**	18.66±1.542***	20.38	74.08
Morphine (5 mg)		6.41±1.165***	2.83±1.260***	86.86	96.11
N + Crd	150 mg	47.15±1.75	63.60±1.542	5.75	11.66
	300 mg	47.70±1.50	64.50±1.428	4.65	10.41
N + Chf	100 mg	47.80±1.25	65.35±1.30	4.45	9.30
	200 mg	48.05±1.33	66.65±1.45	3.95	7.43
N + EtOA	100 mg	47.75±1.23	64.85±1.40	4.55	9.93
	200 mg	47.95±1.25	65.95±1.416	4.15	8.40
N+ Indomethacin (10 mg)		44.00±1.84**	25.00 ±1.539***	12.05	65.27
N + Morphine (5 mg)		47.66±1.52	71.83±1.142	2.39	1.37

All the values were expressed as mean ±SEM. *P<0.05, **P<0.01 and ***P<0.001 whencompared to control group (one way ANOVA followed by Dunnett’s: compare all vscontrol test)
Key: Crd crude methanolic extract, chf chloroform fraction, EtOA ethyl acetate fraction, N naloxone 2 mg