Hepatoprotective action of various partitions of methanol extract of Bauhinia purpurea leaves against paracetamol-induced liver toxicity: involvement of the antioxidant mechanisms

Table 6 Effect of PEBP, EABP and AQBP on percentage change of liver weight in PCM- treated rats

Treatment	Dose (mg/kg)	Change of body weight (%)	Liver/body weight ratio (g/100 g)
Normal control	-	5.14 ± 0.43	2.86 ± 0.05
10 % DMSO + PCM		17.58 ± 2.10^a	4.58 ± 0.33^a
Silymarin + PCM	200	3.11 ± 0.67^b	3.59 ± 0.10^b
PEBP + PCM	50	14.20 ± 1.64	4.24 ± 0.14
	250	14.69 ± 2.60	4.20 ± 0.32
	500	15.84 ± 1.34	3.82 ± 0.05^a
EABP + PCM	50	15.20 ± 1.07	4.53 ± 0.32
	250	3.72 ± 1.10 ^b	4.62 ± 0.17
	500	4.01 ± 0.98 ^b	3.95 ± 0.19^a
AQBP + PCM	50	9.78 ± 1.13 ^b	4.16 ± 0.11
	250	8.26 ± 0.91 ^b	4.39 ± 0.21
	500	14.26 ± 1.76	4.18 ± 0.25

Values are expressed as means ± S.E.M. of six replicates
^a Significant different (p < 0.05) when compared to the normal control group ((10 % DMSO + dH₂O)-treated) of the respective column
^b Significant different (p < 0.05) when compared to the negative control group ((10 % DMSO + PCM)-treated) of the respective column

ISSN: 2662-7671