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Table 5 Effect of sub-inhibitory concentrations of Nauclea latifolia leaves extract on the activities of first line antibiotics against Gram-negative MDR bacteria

From: Antibacterial and antibiotic-modulation activity of six Cameroonian medicinal plants against Gram-negative multi-drug resistant phenotypes

Antibiotics and concentrations of extract

Bacterial strains and MIC values (μg/mL)

PBSS (%)

K. pneumoniae K24

P. stuartii NAE16

E. coli AG100

E. aerogenes EA289

P. aeruginosa PA124

E. aerogenes CM64

TET

0

64

64

16

8

16

32

-

MIC/2

64(1)I

32(2)S

8(2)S

2(4)S

16(1)I

32(1)I

50.00

MIC /5

64(1)I

32(2)S

8(2)S

4(2)S

16(1)I

32(1)I

50.00

NOR

0

≥64

1

≤0.25

-

128

2(1)I

-

MIC/2

≥64

1(1)I

≤0.25

-

128 (1)I

2(1)I

0

MIC /5

≥64

1(1)I

≤0.25

-

128 (1)I

2(1)I

0

STR

0

2

32

≥256

64

64

16

-

MIC/2

2(1)I

16(2)S

32(≥8)S

16(4)S

64(1)I

2(8)S

50.00

MIC /5

2(1)I

32(1)I

32(≥8)S

32(2)S

64(1)I

8(2)S

50.00

KAN

0

8

8

8

32

64

≤2

 

MIC/2

8(1)I

8(1)I

2(4)S

16(2)S

64(1)I

≤2

33.33

MIC /5

8(1)I

8(1)I

4(2)S

32(1)I

64(1)I

≤2

16.67

CHL

0

16

8

8

512

64

512

-

MIC/2

16(1)I

4(2)S

8(1)I

256(2)S

64(1)I

512

33.33

MIC /5

16(1)I

4(2)S

8(1)I

256(2)S

64(1)I

512

33.33

ERY

0

128

16(1)I

64

128

128

256

-

MIC/2

128(1)I

16(1)I

64(1)I

128(1)I

128(1)I

256(1)I

0

MIC /5

128(1)I

16(1)I

64(1)I

128(1)I

128(1)I

256(1)I

0

AMP

0

-

-

128

-

-

-

-

MIC/2

-

-

64(2)S

-

-

-

16.67

MIC /5

-

-

128(1)I

-

-

-

0

  1. (-) : >256 μg/ml; (): fold decrease in MIC values of the antibiotics after association with plants extract; S: Synergy, I: Indifference; A: antagonism, Antibotics (CHL chloramphenicol, AMP ampicillin, KAN kanamycin, NOR norfloxacin, ERY erythromycin, TET tetracycline, STR streptomycin); PBSS percentage of bacteria strain on which synergism has been observed