Table 3 Effect of sub-inhibitory concentrations of Anthocleista schweinfurthii fruits extract on the activities of first line antibiotics against Gram-negative MDR bacteria

TET

0

64

64

16

8

16

32

-

MIC/2

64

64(1)^I

8(2)^S

8(1)^I

64(0.25) ^A

16(2)^S

33.33

MIC /5

64

64(1)^I

8(2)^S

8(1)^I

64(0.25)^A

16(2)^S

33.33

NOR

0

≥64

1

≤0.25

-

128

2(1)^I

-

MIC/2

≥64

1(1)^I

≤0.25

-

128 (1)^I

2(1)^I

0

MIC/5

≥64

1(1)^I

≤0.25

-

128 (1)^I

2(1)^I

0

STR

0

2

32

≥256

64

64

16

-

MIC/2

2(1)^I

16(2)^S

≥256

8(8)^S

32(2)^S

16(1)^I

50

MIC/5

2(1)^I

32(1)^I

≥256

8(8)^S

32(2)^S

16(1)^I

33.33

KAN

0

8

8

8

32

64

≤2

-

MIC/2

8(1)^I

8(1)^I

2(4)^S

2(16)^S

32(2)^S

≤2

50

MIC/5

8(1)^I

8(1)^I

4(2)^S

2(16)^S

32(2)^S

≤2

50

CHL

0

16

8

8

512

64

512

-

MIC/2

8(2)^S

(2)^S

8(1)^I

256(2)^S

64(1)^I

256(2)^S

66.67

MIC/5

8(2)^S

(2)^S

8(1)^I

512(1)^I

64(1)^I

256(2)^S

50

ERY

0

128

16(1)^I

64

128

128

256

-

MIC/2

64(2)^S

16(1)^I

64(1)^I

128(1)^I

128(1)^I

128(2)^S

33.33

MIC/5

128(1)^I

16(1)^I

64(1)^I

128(1)^I

128(1)^I

128(2)^S

16.67

AMP

0

-

-

128

-

-

-

-

MIC/2

-

-

32(4)^S

-

-

-

16.67

MIC/5

-

-

128(1)^I

-

-

-

0