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Fig. 4 | BMC Complementary and Alternative Medicine

Fig. 4

From: Rhus verniciflua Stokes (RVS) and butein induce apoptosis of paclitaxel-resistant SKOV-3/PAX ovarian cancer cells through inhibition of AKT phosphorylation

Fig. 4

RVS and butein inhibit AKT signaling in SKOV-3/PAX cells for 2 hours. (a and b) The expression of AKT, Raf-1, ERK, p38, and JNK in cell lysates from SKOV-3/PAX cells treated with RVS or butein were determined by Western blot assay. (c) SKOV-3/PAX cells were pretreated with AKT inhibitor, LY294002 (50 μM) for 1 hour and then added with RVS or butein for another 24 hours. The expression levels of AKT phosphorylation and PARP cleavage were determined by Western blot assay. (d) A schematic model for the apoptosis via inhibition of AKT activity by RVS or butein

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