Antimalarial properties of crude extracts of seeds of Brucea antidysenterica and leaves of Ocimum lamiifolium

Table 3 Antimalarial activities of aqueous, methanol and chloroform extracts of leaves of O. lamiifolium and mean survival time of P. berghie infected mice

Extraction solvents	Dose (mg/kg)	Extract antimalarial activity on D4 post-infection		Mean survival time (days)
Extraction solvents	Dose (mg/kg)	% Parasitaemia ± SEM	% suppression
dH₂O	200	35.68 ± 1.42	22.16	10.95 ± 1.04^*
	400	33.57 ± 2.81	26.76	11.65 ± 0.65^*
	600	29.55 ± 0.89	35.53	12.50 ± 0.41^*
CH₃OH	200	33.83 ± 3.43	24.95	10.00 ± 1.70^*
	400	34.00 ± 5.92	24.57	12.80 ± 0.76^*
	600	33.33 ± 11.69	26.06	11.00 ± 0.80^*
CHCL₃	200	38.00 ± 3.88	15.70	9.40 ± .67^*
	400	36.42 ± 2.01	19.21	9.80 ± 0.67^*
	600	35.75 ± 3.37	20.69	9.60 ± 1.51
Control	CQ (25 mg)	0.00 ± 0.00	100.00	ND
Control	T80	45.84 ± 2.11	0.00	7.00 ± 0.50

Key: Values are presented as M ± SEM; n = 5; T80 = negative control (3 % tween 80); CQ positive control (chloroquine), ND no death within the follow-up interval (30-days), dH ₂ O distilled water, CH ₃ OH methanol, CHCl ₃ chloroform, CQ chloroquine (positive control); ^* = values are significantly different (p < 0.05) from that of the negative control

ISSN: 2662-7671