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Table 3 Antimalarial activities of aqueous, methanol and chloroform extracts of leaves of O. lamiifolium and mean survival time of P. berghie infected mice

From: Antimalarial properties of crude extracts of seeds of Brucea antidysenterica and leaves of Ocimum lamiifolium

Extraction solvents Dose (mg/kg) Extract antimalarial activity on D4 post-infection Mean survival time (days)
% Parasitaemia ± SEM % suppression  
dH2O 200 35.68 ± 1.42 22.16 10.95 ± 1.04*
400 33.57 ± 2.81 26.76 11.65 ± 0.65*
600 29.55 ± 0.89 35.53 12.50 ± 0.41*
CH3OH 200 33.83 ± 3.43 24.95 10.00 ± 1.70*
400 34.00 ± 5.92 24.57 12.80 ± 0.76*
600 33.33 ± 11.69 26.06 11.00 ± 0.80*
CHCL3 200 38.00 ± 3.88 15.70 9.40 ± .67*
400 36.42 ± 2.01 19.21 9.80 ± 0.67*
600 35.75 ± 3.37 20.69 9.60 ± 1.51
Control CQ (25 mg) 0.00 ± 0.00 100.00 ND
T80 45.84 ± 2.11 0.00 7.00 ± 0.50
  1. Key: Values are presented as M ± SEM; n = 5; T80 = negative control (3 % tween 80); CQ positive control (chloroquine), ND no death within the follow-up interval (30-days), dH 2 O distilled water, CH 3 OH methanol, CHCl 3 chloroform, CQ chloroquine (positive control); * = values are significantly different (p < 0.05) from that of the negative control