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Table 2 Effect of aqueous, methanol and chloroform crude extracts of seeds of Brucea antidysentmerica on body weight and PCV of P. berghei infected mice

From: Antimalarial properties of crude extracts of seeds of Brucea antidysenterica and leaves of Ocimum lamiifolium

Extracts/treatments

Dose (mg/kg)

PCV

Body weight

D0

D-4

D0

D-4

NC

 

53.37 ± 0.75

46.67 ± 1.79b

28.70 ± 3.24

27.60 ± 3.88

dH2O

200

56.99 ± 2.02

45.10 ± 0.65b

32.25 ± 1.22

29.75 ± 0.09a

 

400

56.84 ± 2.83

43.53 ± 5.08b

31.50 ± 0.79

30.24 ± 0.52a

 

600

55.74 ± 1.00

48.62 ± 1.93b

25.80 ± 0.89

31.10 ± 1.37b

CH3OH

200

50.78 ± 0.96

51.29 ± 0.29a

28.56 ± 1.41

31.22 ± 1.40b

 

400

53.19 ± 1.09

53.26 ± 2.20a

34.10 ± 2.58

36.09 ± 2.16b

 

600

56.62 ± 1.90

50.40 ± 3.55b

31.50 ± 2.30

33.35 ± 1.86b

CHCl3

200

55.67 ± 1.38

52.89 ± 1.30a

30.95 ± 2.25

32.36 ± 0.28b

 

400

52.09 ± 2.83

53.09 ± 0.95a

29.6 ± 1.83

31.25 ± 0.44b

 

600

51.8 ± 1.59

51.27 ± 1.95a

29.5 ± 1.41

29.39 ± 0.5a

CQ

25

52.27 ± 0.74

51.82 ± 0.82a

30.54 ± 0.37

33 ± 0.37b

  1. Key: Values are presented as mean ± SEM; n = 5; PCV packed cell volume, NC negative control (3 % tween 80), dH2O distilled water, CH 3 OH methanol, CHCl 3 chloroform, CQ chloroquine (positive control); a = the difference between day 0 and day 4 is not significant (P > 0.05); b = the difference between day 0 and day 4 is significant (P < 0.05)