TY - JOUR AU - Park, Jong-Shik AU - Lim, Chae Jun AU - Bang, Ok-Sun AU - Kim, No Soo PY - 2016 DA - 2016/04/02 TI - Ethanolic extract of Descurainia sophia seeds sensitizes A549 human lung cancer cells to TRAIL cytotoxicity by upregulating death receptors JO - BMC Complementary and Alternative Medicine SP - 115 VL - 16 IS - 1 AB - Our previous genome-wide gene expression analysis revealed that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptors 4 (DR4) and 5 (DR5) are markedly upregulated by the ethanolic extract of D. sohia seeds (EEDS) in A549 TRAIL-refractory cancer cells. In the present study, we investigated whether the EEDS-mediated upregulation of TRAIL death receptors was associated with increased TRAIL-mediated toxicity in A549 cells in vitro. SN - 1472-6882 UR - https://doi.org/10.1186/s12906-016-1094-0 DO - 10.1186/s12906-016-1094-0 ID - Park2016 ER -