Skip to main content

Table 3 Characteristics of included studies

From: Evidence-based review of oral traditional Chinese medicine compound recipe administration for treating weight drop-induced experimental traumatic brain injury

Study

Animal Species

Treatment Groups(Drug/Dose)

Anaesthetic used

Time of administration

Main Outcomes

Quality Score

Long 2001 [1]

Mixed Kunming mice

Naozhenning Granule(13.33 g/kg)

Naochuangning (9.08 g/kg)

Naochuangning (18.16 g/kg)

Naochuangning (36.33 g/kg)

Unknown

7 days before injury

Daily for 10 days

Cerebral edema

BBB permeability

2

Zhang 2002 [3]

SD rats

Brain injury compound decoction (unknown)

Ether

3 days before injury

Daily for 10 days

Independent activity

Cognitive performance

4

Wang 2003 [4]

Mixed

Wistar rats

Naozhenning Granule(13.13 g/kg)

Naochuangning (9.15 g/kg)

Naochuangning(19.10 g/kg)

Naochuangning (38.10 g/kg)

Pentobarbital

After injury

Daily for 14 days

Memory performance

Endothelia content

4

Zhang 2004 [5]

SD rats

Tongfujiannao Oral Liquid(7.5 g/kg)

Tongfujiannao Oral Liquid(3.125 g/kg)

Unknown

After injury

Daily for 3 days

Brain water content MDA\SOD content(Brain) \LPS content(Plasma) Histopathological

3

Cui 2005a [6]

Male SD rats

Naoshuning(15 g/kg)

chloral

hydrate

3 days before injury

Twice for 4 days

Neurological function

Histopathological

Brain water conte

3

Cui 2005b [7]

Male

SD rats

Naoshuning(15 g/kg)

chloral

hydrate

3 days before injury

Twice for 4 days

BBB permeability

Brain water content

MMP-9

3

Yu 2005 [8]

Kunming

mice

Shenqi Extraction (0.28 g/kg)

Shenqi Extraction (0.14 g/kg)

Shenqi Extraction (0.07 g/kg)

Ether

3 days before injury

Daily for 3 days

BBB permeability

Brain water content

TNF-α(Brain)\ ET content(Serum)

4

Zhou 2007 [9]

Mixed

SD rats

Huayu capsule (1.030 g/kg)

Huayu capsule (0.515 g/kg)

Huayu capsule (0.258 g/kg)

chloral

hydrate

After injury

Daily for 7 days

Nerve-muscle catching capability.

Histopathological

3

Cui 2008a [10]

Male

SD rats

Naoshuning(7.5 g/kg)

chloral

hydrate

3 days before injury

Twice for 4 days

Brain water content

BBB permeability

AQP-4 content

3

Cui 2008b [11]

Male

SD rats

Naoshuning(7.5 g/kg)

Unknown

3 days before injury

Twice for 4 days

BBB permeability

Histopathological cerebral microvascular density

3

Miao 2008 [12]

Male

Wistar rats

Brain Compound decoction(10 g/kg)

Pentobarbital

Immediately after injury

Twice for 7 days

Na+-K+-ATP

Ca2+-ATP

5

Cui 2009a [13]

SD rats

Naoshuning(7.5 g/kg)

Unknown

3 days before injury

Daily for 3 days

Histopathological (HE statin)

Edema volume

Brain water content

3

Cui 2009b [14]

Male

SD rats

Naoshuning(7.5 g/kg)

Unknown

3 days before injury

Twice for 8 days

MMP-2/9 content

Brain water content

EB content

3

Xiong 2009 [15]

SD rats

Quyu Tongfu decoction(10 ml/kg)

compound Huangjinxiang extraction liquid(10 ml/kg)

Pentobarbital

20 min after injury

Daily for 24 h

AQP- 4 content

5

Xie 2010 [16]

Mixed

SD rats

Angong Niuhuang Pill(0.6 g/kg)

chloral

hydrate

12 h before injury

Twice for 60 h

Synaptic density

BBB permeability

Cerebral edema

3

Xu 2010 [17]

Mixed

SD rats

Angong Niuhuang Pill

(0.121 g/2 ml)

Pentobarbital

After injury

Daily for 12 days

ApoE content (Brain and CSF)

4

Miao 2011 [18]

Male

Wistar rats

Brain Compound decoction(10 g/kg)

Pentobarbital

Immediately after injury

Twice for 7 days

NO\nNOS(Brain)

Brain water content

Histopathological

5

Zhang 2011 [19]

Wistar rats

Sanhuang Xiexin Decoction(10 g/kg)

chloral

hydrate

Immediately after injury

Daily for 72 h

NF-κB\IL- 6 content

3

Wang 2012a [20]

SD rats

Longxuejie capsule (2.6 mg/g/d)

Unknown

after injury

Daily for 5d

NO\TNF-α content (serum)

3

Wang 2012b [21]

Male

SD rats

modified “Shengyu”decoction 4.0 mL/200 g/d

Unknown

6 h after injury

Twice for 72 h

Histopathological caspase-3 activity

3

Zhao 2012 [22]

Mixed

SD rats

JiannaoYizhi capsules(6.0 g/kg/d)

chloral hydrate

24 h after injury

Daily for 10d

CGRP content (Plasma)

3

Zhou 2012 [23]

SD rats

JiannaoYizhi capsules(6.0 g/kg/d)

chloral hydrate

24 h after injury

Daily for 10d

NPY content (serum)

3

Fan 2013a [24]

SD rats

JiannaoYizhi capsules(6.0 g/kg/d)

chloral hydrate

24 h after injury

Daily for 10d

S100B content (serum)

3

Fan 2013b [25]

SD rats

JiannaoYizhi capsules(6.0 g/kg/d)

chloral hydrate

24 h after injury

Daily for 10d

NSE content (serum)

3

Zhao 2014 [26]

Male

SD rats

modified “Shengyu”decoction 0.5 mL/200 g

modified “Shengyu”decoction 1.0 mL/200 g

modified “Shengyu”decoction 2.0 mL/200 g

chloral hydrate

6 h after injury

Daily for 7d

Neurological function

Brain water content

Histopathological

Lesion volume

TNF-α\ IL-1\IL-6\IL-10 content (brain)

6

  1. Note: BBB Blood–brain-barrier, MMP-9 matrix metalloprotein 9, TNF-α tumor necrosis factor-α, IL-1 interleukin-1, IL-6 interleukin-6, IL-10 interleukin-10, NSE 2-phospho-D-glycerate hydrolase, NPY Neuropeptide Y, CGRP Calcitonin Gene Related Peptide, SOD superoxidedismutase, MDA malondialdehyde, NO Nitrogen monoxide, SD Sprague Dawley.-