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Table 3 Characteristics of included studies

From: Evidence-based review of oral traditional Chinese medicine compound recipe administration for treating weight drop-induced experimental traumatic brain injury

Study Animal Species Treatment Groups(Drug/Dose) Anaesthetic used Time of administration Main Outcomes Quality Score
Long 2001 [1] Mixed Kunming mice Naozhenning Granule(13.33 g/kg)
Naochuangning (9.08 g/kg)
Naochuangning (18.16 g/kg)
Naochuangning (36.33 g/kg)
Unknown 7 days before injury
Daily for 10 days
Cerebral edema
BBB permeability
2
Zhang 2002 [3] SD rats Brain injury compound decoction (unknown) Ether 3 days before injury
Daily for 10 days
Independent activity
Cognitive performance
4
Wang 2003 [4] Mixed
Wistar rats
Naozhenning Granule(13.13 g/kg)
Naochuangning (9.15 g/kg)
Naochuangning(19.10 g/kg)
Naochuangning (38.10 g/kg)
Pentobarbital After injury
Daily for 14 days
Memory performance
Endothelia content
4
Zhang 2004 [5] SD rats Tongfujiannao Oral Liquid(7.5 g/kg)
Tongfujiannao Oral Liquid(3.125 g/kg)
Unknown After injury
Daily for 3 days
Brain water content MDA\SOD content(Brain) \LPS content(Plasma) Histopathological 3
Cui 2005a [6] Male SD rats Naoshuning(15 g/kg) chloral
hydrate
3 days before injury
Twice for 4 days
Neurological function
Histopathological
Brain water conte
3
Cui 2005b [7] Male
SD rats
Naoshuning(15 g/kg) chloral
hydrate
3 days before injury
Twice for 4 days
BBB permeability
Brain water content
MMP-9
3
Yu 2005 [8] Kunming
mice
Shenqi Extraction (0.28 g/kg)
Shenqi Extraction (0.14 g/kg)
Shenqi Extraction (0.07 g/kg)
Ether 3 days before injury
Daily for 3 days
BBB permeability
Brain water content
TNF-α(Brain)\ ET content(Serum)
4
Zhou 2007 [9] Mixed
SD rats
Huayu capsule (1.030 g/kg)
Huayu capsule (0.515 g/kg)
Huayu capsule (0.258 g/kg)
chloral
hydrate
After injury
Daily for 7 days
Nerve-muscle catching capability.
Histopathological
3
Cui 2008a [10] Male
SD rats
Naoshuning(7.5 g/kg) chloral
hydrate
3 days before injury
Twice for 4 days
Brain water content
BBB permeability
AQP-4 content
3
Cui 2008b [11] Male
SD rats
Naoshuning(7.5 g/kg) Unknown 3 days before injury
Twice for 4 days
BBB permeability
Histopathological cerebral microvascular density
3
Miao 2008 [12] Male
Wistar rats
Brain Compound decoction(10 g/kg) Pentobarbital Immediately after injury
Twice for 7 days
Na+-K+-ATP
Ca2+-ATP
5
Cui 2009a [13] SD rats Naoshuning(7.5 g/kg) Unknown 3 days before injury
Daily for 3 days
Histopathological (HE statin)
Edema volume
Brain water content
3
Cui 2009b [14] Male
SD rats
Naoshuning(7.5 g/kg) Unknown 3 days before injury
Twice for 8 days
MMP-2/9 content
Brain water content
EB content
3
Xiong 2009 [15] SD rats Quyu Tongfu decoction(10 ml/kg)
compound Huangjinxiang extraction liquid(10 ml/kg)
Pentobarbital 20 min after injury
Daily for 24 h
AQP- 4 content 5
Xie 2010 [16] Mixed
SD rats
Angong Niuhuang Pill(0.6 g/kg) chloral
hydrate
12 h before injury
Twice for 60 h
Synaptic density
BBB permeability
Cerebral edema
3
Xu 2010 [17] Mixed
SD rats
Angong Niuhuang Pill
(0.121 g/2 ml)
Pentobarbital After injury
Daily for 12 days
ApoE content (Brain and CSF) 4
Miao 2011 [18] Male
Wistar rats
Brain Compound decoction(10 g/kg) Pentobarbital Immediately after injury
Twice for 7 days
NO\nNOS(Brain)
Brain water content
Histopathological
5
Zhang 2011 [19] Wistar rats Sanhuang Xiexin Decoction(10 g/kg) chloral
hydrate
Immediately after injury
Daily for 72 h
NF-κB\IL- 6 content 3
Wang 2012a [20] SD rats Longxuejie capsule (2.6 mg/g/d) Unknown after injury
Daily for 5d
NO\TNF-α content (serum) 3
Wang 2012b [21] Male
SD rats
modified “Shengyu”decoction 4.0 mL/200 g/d Unknown 6 h after injury
Twice for 72 h
Histopathological caspase-3 activity 3
Zhao 2012 [22] Mixed
SD rats
JiannaoYizhi capsules(6.0 g/kg/d) chloral hydrate 24 h after injury
Daily for 10d
CGRP content (Plasma) 3
Zhou 2012 [23] SD rats JiannaoYizhi capsules(6.0 g/kg/d) chloral hydrate 24 h after injury
Daily for 10d
NPY content (serum) 3
Fan 2013a [24] SD rats JiannaoYizhi capsules(6.0 g/kg/d) chloral hydrate 24 h after injury
Daily for 10d
S100B content (serum) 3
Fan 2013b [25] SD rats JiannaoYizhi capsules(6.0 g/kg/d) chloral hydrate 24 h after injury
Daily for 10d
NSE content (serum) 3
Zhao 2014 [26] Male
SD rats
modified “Shengyu”decoction 0.5 mL/200 g
modified “Shengyu”decoction 1.0 mL/200 g
modified “Shengyu”decoction 2.0 mL/200 g
chloral hydrate 6 h after injury
Daily for 7d
Neurological function
Brain water content
Histopathological
Lesion volume
TNF-α\ IL-1\IL-6\IL-10 content (brain)
6
  1. Note: BBB Blood–brain-barrier, MMP-9 matrix metalloprotein 9, TNF-α tumor necrosis factor-α, IL-1 interleukin-1, IL-6 interleukin-6, IL-10 interleukin-10, NSE 2-phospho-D-glycerate hydrolase, NPY Neuropeptide Y, CGRP Calcitonin Gene Related Peptide, SOD superoxidedismutase, MDA malondialdehyde, NO Nitrogen monoxide, SD Sprague Dawley.-