Table 3 Effects of different treatments on the biochemical parameters of oxidative stress and hepatotoxicity
From: Cycloartanes from Oxyanthus pallidus and derivatives with analgesic activities
Parameters | Tissue | Control | Diclofenac (5 mg/kg) | OP5 (2.5 mg/kg) | OP5 (5 mg/kg) |
|---|---|---|---|---|---|
NO (μmol/g tissue) | liver | 0.49 ± 0.06 | 0.28 ± 0.06* | 0.48 ± 0.04 | 0.36 ± 0.03 |
kidney | 1.014 ± 0.11 | 0.66 ± 0.15 | 1.23 ± 0.15 | 0.85 ± 0.06 | |
Glutathione (μmol/g tissue) | liver | 0.12 ± 0.01 | 0.11 ± 0.01 | 0.12 ± 0.01 | 0.10 ± 0.01 |
kidney | 0.07 ± 0.01 | 0.04 ± 0.01 | 0.09 ± 0.01 | 0.07 ± 0.00 | |
MDA (μmol/g tissue) | liver | 9.37 ± 0.74 | 9.80 ± 0.46 | 3.10 ± 0.37*** | 9.42 ± 0.24 |
kidney | 0.12 ± 0.01 | 0.09 ± 0.02 | 0.14 ± 0.01 | 0.12 ± 0.00 | |
SOD (U/mg protein) | liver | 0.05 ± 0.01 | 0.12 ± 0.00* | 0.08 ± 0.02 | 0.11 ± 0.01* |
kidney | 0.19 ± 0.08 | 0.12 ± 0.05 | 0.09 ± 0.02 | 0.10 ± 0.04 | |
Catalase (U/mg protein) | kidney | 0.08 ± 0.01 | 0.08 ± 0.01 | 0.10 ± 0.02 | 0.08 ± 0.01 |
ALAT (U/mg protein) | serum | 0.39 ± 0.15 | 0.4 ± 0.01 | 0.60 ± 0.08 | 0.80 ± 0.21 |
ASAT (U/mg protein) | serum | 1.28 ± 0.10 | 1.58 ± 0.13 | 1.35 ± 0.07 | 1.313 ± 0.11 |