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Fig. 4 | BMC Complementary and Alternative Medicine

Fig. 4

From: Rg3-enriched ginseng extract ameliorates scopolamine-induced learning deficits in mice

Fig. 4

Effect of Rg3GE on scopolamine-induced impairment of spatial memory during the training period for the Morris water maze test. a Rg3GE (50 or 100 mg/kg, p.o.) or RGE (100 mg/kg, p.o.) was administered prior to the training trials for the Morris water maze test (days 1–8) and continued on days 9–14, during which the Morris water maze test was carried out. Impairment of spatial memory was induced by scopolamine (SCO, 1 mg/kg, administered by i.p. injection on days 9–14). During the training period (days 9–14), we evaluated the mean search error. b On days 12 and 14, probe trials were conducted to measure the retention of spatial memory. In the probe trial on day 14, vehicle control mice spent significantly more time in the target quadrant than did scopolamine-treated mice (#). However, Rg3GE or RGE treatments did not improve performance of the scopolamine-treated mice. Statistical analysis was performed by one-way repeated ANOVA, followed by Fisher’s LSD test. Data are expressed as mean ± SEM (n = 10)

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