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Table 5 Effect of EAF on levels of PGE2 and NO in the stomach tissue of the ethanol-treated rats

From: Mechanism(s) of action underlying the gastroprotective effect of ethyl acetate fraction obtained from the crude methanolic leaves extract of Muntingia calabura

Experimental groups Dose (mg/kg) Prostaglandin E2(pg/mg protin) NO (μM/g tissue)
Normal (untreated) - 188.39 ± 4.66** 43.06 ± 4.83**
Vehicle + ethanol - 159.90 ± 6.49## 22.25 ± 1.65##
Ranitidine + ethanol 100 186.88 ± 3.39** 45.73 ± 4.22**
EAF + ethanol 100 178.12 ± 5.07 42.61 ± 2.25**
  250 191.94 ± 5.24*** 47.25 ± 4.46***
  500 201.07 ± 4.20*** 56.47 ± 4.61***
  1. Values are expressed as mean ±  SEM for six animals in each group. One way ANOVA was followed by Dunnett's post hoc test, *p < 0.05, **p < 0.01, and ***p < 0.001 as compared to the vehicle group. Student’s t-test was performed for comparing normal and vehicle group, significant at## p < 0.01