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Table 4 Effect of EAF on levels of SOD, GSH, CAT and MDA in the stomach tissue of the ethanol-treated rats

From: Mechanism(s) of action underlying the gastroprotective effect of ethyl acetate fraction obtained from the crude methanolic leaves extract of Muntingia calabura

Experimental groups Dose (mg/kg) SOD (U/mg protein) Total GSH (mM/ mg protein) CAT (U/ mg protein) MDA (ng/mg protin)
Normal (untreated) - 4.90 ± 0.21** 43.35 ± 2.02*** 60.59 ± 0.87* 3.11 ± 0.14***
Vehicle + ethanol - 4.00 ± 0.13## 16.76 ± 1.73### 55.48 ± 0.76## 6.66 ± 0.26###
Ranitidine + ethanol 100 5.00 ± 0.15** 55.60 ± 1.65*** 63.87 ± 0.62*** 3.34 ± 0.18***
EAF + ethanol 100 4.74 ± 0.16* 46.48 ± 3.63*** 62.85 ± 2.31** 3.19 ± 0.16***
  250 5.41 ± 0.28*** 55.72 ± 3.37*** 63.34 ± 1.12*** 2.92 ± 0.11***
  500 6.22 ± 0.16*** 56.04 ± 3.26*** 65.61 ± 1.28*** 2.86 ± 0.10***
  1. Values are expressed as mean ±  SEM for six animals in each group. One way ANOVA was followed by Dunnett's post hoc test, *p < 0.05, **p < 0.01, and ***p < 0.001 as compared to the vehicle group. Student’s t-test was performed for comparing normal and vehicle groups, significant at ## p < 0.01, and ### p < 0.001
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