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Table 4 Effect of EAF on levels of SOD, GSH, CAT and MDA in the stomach tissue of the ethanol-treated rats

From: Mechanism(s) of action underlying the gastroprotective effect of ethyl acetate fraction obtained from the crude methanolic leaves extract of Muntingia calabura

Experimental groups

Dose (mg/kg)

SOD (U/mg protein)

Total GSH (mM/ mg protein)

CAT (U/ mg protein)

MDA (ng/mg protin)

Normal (untreated)

-

4.90 ± 0.21**

43.35 ± 2.02***

60.59 ± 0.87*

3.11 ± 0.14***

Vehicle + ethanol

-

4.00 ± 0.13##

16.76 ± 1.73###

55.48 ± 0.76##

6.66 ± 0.26###

Ranitidine + ethanol

100

5.00 ± 0.15**

55.60 ± 1.65***

63.87 ± 0.62***

3.34 ± 0.18***

EAF + ethanol

100

4.74 ± 0.16*

46.48 ± 3.63***

62.85 ± 2.31**

3.19 ± 0.16***

 

250

5.41 ± 0.28***

55.72 ± 3.37***

63.34 ± 1.12***

2.92 ± 0.11***

 

500

6.22 ± 0.16***

56.04 ± 3.26***

65.61 ± 1.28***

2.86 ± 0.10***

  1. Values are expressed as mean ±  SEM for six animals in each group. One way ANOVA was followed by Dunnett's post hoc test, *p < 0.05, **p < 0.01, and ***p < 0.001 as compared to the vehicle group. Student’s t-test was performed for comparing normal and vehicle groups, significant at ## p < 0.01, and ### p < 0.001