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Table 3 Effect of EAF on gastric juice parameters in pylorus-ligated rat model

From: Mechanism(s) of action underlying the gastroprotective effect of ethyl acetate fraction obtained from the crude methanolic leaves extract of Muntingia calabura

Treatment Volume of gastric juice (ml) pH Free acidity (meq/l) Total acidity (mEq/l) Total protein (mg/ml)
Control (8 % tween 80) 7.75 ± 1.18 1.26 ± 0.08 103.30 ± 7.53 142.50 ± 9.69 5.45 ± 0.17
Ranitidine 2.25 ± 0.38*** 2.73 ± 0.38** 52.67 ± 5.70*** 80.67 ± 7.87*** 3.78 ± 0.28***
EAF 100 mg/kg 3.38 ± 0.86** 1.97 ± 0.31 97.00 ± 8.42 128.70 ± 4.22 4.32 ± 0.31**
250 mg/kg 1.83 ± 0.23*** 1.94 ± 0.20 62.83 ± 7.08*** 99.00 ± 6.46*** 4.61 ± 0.10*
500 mg/kg 4.02 ± 0.64** 1.69 ± 0.25 77.50 ± 3.43* 115.20 ± 4.80* 4.50 ± 0.13*
  1. Values are expressed as mean ±  SEM for six animals in each group. One way ANOVA was followed by Dunnett's post hoc test, *p < 0.05, **p < 0.01, and ***p < 0.001 as compared to the control group