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Table 1 Characteristics of included studies

From: Effectiveness and safety of ShenXiong glucose injection for acute ischemic stroke: a systematic review and GRADE approach

First author

Number of patients (n)

Age (years, Mean ± SD)

Diagnostic criteria

Onset (days)

Baseline NFDS (Mean ± SD)

Dose of Experiment

Conventional measure (CM)

Setting

E

C

E

C

E

C

Wang 2014 [32]

35

35

67.24 ± 4.38

68.15 ± 5.0

CT,MRI

≤3d

18.15 ± 8.14

17.96 ± 8.02

Danshen Ligustrazine 10 ml/d + 250 ml glucose + CM

antihypertensive, anti platelet aggregation

Inpatients

Liu 2014 [30]

71

71

53.1 ± 1.7

49.7 ± 2.1

CT,MRI

≤3d

22.49 ± 1.21

23.18 ± 1.74

Danshen Ligustrazine 13–15 ml/d + 250 ml glucose + CM

antihypertensive, reduce ICP

Inpatients

Liu 2011 [39]

34

33

41–79

40–80

CT,MRI

≤3d

17.2 ± 2.0

16.7 ± 3.2

Danshen Ligustrazine 10 ml/d + 250 ml glucose + CM

anticoagulation, nutrition brain cells

Inpatients

Zhou 2013 [37]

50

50

54.2 ± 4.1

54.2 ± 4.1

NR

≤3d

NR

NR

Danshen Ligustrazine 10 ml/d + 250 ml glucose + CM

Anti-platelet aggregation, reduce ICP

Inpatients

Huang 2012 [40]

38

30

64.3 ± 5.6

66.3 ± 5.3

CT,MRI

NR

NR

NR

ShenXiong glucose 200 ml plus CM

nutrition brain cells, reduce ICP

Inpatients

Zhou 2011 [34]

40

40

42–75

42–75

CT,MRI

NR

22 ± 10

23 ± 10

ShenXiong glucose 200 ml plus CM

antihypertensive, reduce ICP

Inpatients

Shan 2013 [31]

30

30

65

64

CT,MRI

≤3d

22.50 ± 8.03

21.65 ± 6.2

ShenXiong glucose 200 ml plus CM

antihypertensive, anti platelet aggregation

Inpatients

Zhe 2011 [33]

30

31

57.34 ± 8.97

58.26 ± 7.48

CT,MRI

≤2d

24.63 ± 9.28

23.68 ± 7.89

ShenXiong glucose 200 ml plus CM

nutrition brain cells, reduce ICP, anti-platelet aggregation

Inpatients

Ling 2013 [41]

40

40

56.3 ± 12.5

58.3 ± 11.8

CT,MRI

≤3d

NR

NR

ShenXiong 10 ml/d + 250 ml glucose + CM

anti platelet aggregation, nutrition brain cells

Inpatients

Guan 2011 [42]

46

40

63 ± 3

63 ± 3

CT,MRI

NR

NR

NR

ShenXiong glucose 200 ml plus CM

reduce ICP, nutrition brain cells

Inpatients

Nie 2013 [35]

35

35

55–71

54–70

CT,MRI

NR

25.63 ± 9.08

24.68 ± 7.59

ShenXiong glucose 200 ml plus CM

anti platelet aggregation, nutrition brain cells

Inpatients

Lin 2014 [36]

43

43

55.6 ± 9.31

52.8 ± 8.72

CT,MRI

≤3d

NR

NR

ShenXiong 10 ml/d + 250 ml glucose + CM

anti-hypertensive, anti-platelet aggregation

Inpatients

  1. Notes: SD standard deviation, NR not report, NFDS neurological function deficit score, CM Conventional Measure, CT Computed Tomography, MRI Magnetic Resonance Imaging, E experiment group, C control group