Fig. 3

F. mume treatment ameliorated impairments in recognition and fear memory in 5XFAD mice. a The object/location novelty recognition test consisted of a novel object and novel location phase. During the object phase, no significant differences in the preference for a novel object were observed between the groups, whereas, during the subsequent novel location phase, vehicle-treated 5XFAD mice exhibited less preference for the object moved to the novel location than vehicle-treated non-transgenic mice (*p < 0.05), which was reversed by F. mume treatment (^# p < 0.05). b During contextual fear conditioning, mice were exposed to a context (conditioning chamber) for 148 s and then received three unsignaled foot shocks (0.75 mA, 2 s, 30 s interval). Context-associated fear memory was measured by observing freezing behavior 24 h later. During the test phase, vehicle-treated 5XFAD mice exhibited less freezing behavior than vehicle-treated non-transgenic mice (*p < 0.05), which was reversed by treatment of F. mume (^# p < 0.05). During the baseline, prior to the foot shock delivery, vehicle-treated 5XFAD mice exhibited more activity than mice in the other groups (*^,# p < 0.05) (n = 16 – 17 per group). All the data are presented as the mean ± SEM