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Table 2 Effect of B. crispa and some pure compounds isolated from the plant in formalin test in mice

From: Analgesic, anti-inflammatory and anti-platelet activities of Buddleja crispa

Treatment Dose (mg/kg) i.p. Licking time (Sec) % Inhibition
1st Phase 2nd Phase 1st Phase 2nd Phase
Control - 50 ± 3 75 ± 5 - -
B. crispa 50 55 ± 3 42 ± 5** - 44
100 51 ± 4 29 ± 5*** - 61
Hexane fraction 10 47 ± 3 39 ± 5** 6 48
25 52 ± 5 32 ± 6*** - 57
Aqueous fraction 50 43 ± 3 51 ± 5** 14 32
BdI-2 10 47 ± 5 25 ± 4*** - 67
-
BdI-H3 1 49 ± 6 53 ± 3* - 29
5 55 ± 7 46 ± 7**   38
BH-3 10 42 ± 7 37 ± 5** 16 50
Diclofenac sodium 20 47 ± 5 27 ± 6*** - 64
  1. Values represent mean ± S.E.M of 6–30 observations
  2. *P < 0.05
  3. **P < 0.01
  4. ***P < 0.001, compared to control