Skip to main content
Fig. 4 | BMC Complementary and Alternative Medicine

Fig. 4

From: Radix puerariae extracts ameliorate paraquat-induced pulmonary fibrosis by attenuating follistatin-like 1 and nuclear factor erythroid 2p45-related factor-2 signalling pathways through downregulation of miRNA-21 expression

Fig. 4

Effects of RPE on miR-21, FSTL1, p-p38MAPK, NF-kB65, p-Smad2/3, and MMP-9 expression in lungs from mice treated with PQ. On day 14 after administration of RPE and PQ challenge, miR-21, FSTL1, p-p38MAPK, NF-kB65, p-Smad2/3 and MMP-9 expression were assessed by real-time PCR (a) and p-p38MAPK, NF-kB65, p-Smad2/3 and MMP-9 protein levels by western blotting (b) Groups are as defined in Methods. (a, control; b, model group; c, treatment group). Values are means ± SD as determined from three independent experiments. *P < 0.05 and **P < 0.01 vs the control group; # P < 0.05 and # # P < 0.01 vs the model group. (The “model group” for PQ-induced lung fibrosis is defined in Methods.)

Back to article page