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Fig. 3 | BMC Complementary and Alternative Medicine

Fig. 3

From: Radix puerariae extracts ameliorate paraquat-induced pulmonary fibrosis by attenuating follistatin-like 1 and nuclear factor erythroid 2p45-related factor-2 signalling pathways through downregulation of miRNA-21 expression

Fig. 3

Effect of miR-21 knockdown on FSTL1 expression and PQ-induced pulmonary fibrosis. On day 14 after administration of RPE and PQ challenge, FSTL1 expression and pulmonary fibrosis were assessed. a and b Histopathological changes in lung tissues from mice (a: HE staining, 200× magnification; b: Masson’s trichrome staining, 200× magnification; a, control (scrambled oligonucleotide); b, miR-21 knockdown; c, WT); c: Representative western blots showing FSTL1 levels (a, control (scrambled oligonucleotide); b, miR-21 knockdown; c, WT) and statistical analysis of FSTL1 protein levels. Data are expressed as means ± SEM. *P < 0.05, vs the control group; #P < 0.05 vs the miR-21 knockdown group. d Statistical summary of pulmonary fibrosis scores in mice. Pulmonary fibrosis scores and levels of FSTL1 expression were expressed as means ± SD from triplicate experiments. *P < 0.05 vs the control group; #P < 0.05 vs the miR-21 knockdown group

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