Antibacterial and antibiotic-modifying activities of three food plants ( Xanthosoma mafaffa Lam., Moringa oleifera (L.) Schott and Passiflora edulis Sims) against multidrug-resistant (MDR) Gram-negative bacteria

Joachim K. Dzotam; Francesco K. Touani; Victor Kuete

doi:10.1186/s12906-016-0990-7

BMC Complementary Medicine and Therapies

Table 6 MIC (FIC) of different antibiotics after the association of the extract of Moringa oleifera at MIC/2, MIC/4 against ten MDR bacteria strains

From: Antibacterial and antibiotic-modifying activities of three food plants (Xanthosoma mafaffa Lam., Moringa oleifera (L.) Schott and Passiflora edulis Sims) against multidrug-resistant (MDR) Gram-negative bacteria

Antibiotics	Bacterial strains, MIC (μg/mL) of antibiotics in the absence and presence of the extract
Antibiotics	Extract concentration	PA124	AG100	AG102	AG100Atet	EA27	EA289	CM64	KP55	KP63	NEA16	PBSS (%)
CIP	0	16	0.50	0.50	-	1	1	0.50	2	-	1
	CMI/2	32(2)^I	0.50(1)^I	0.50(1)^I	-(na)	1(1)^I	0.50(0.50) ^S	4(8)^A	<0.50(na) ^S	-(na)	1(1)^I	20
	CMI/4	32(2)^I	0.50(1)^I	0.50(1)^I	-(na)	1(1)^I	0.50(0.50) ^S	8(16)^A	<0.50(na) ^S	-(na)	1(1)^I	20
NOR	0	128	2	1	-	4	8	4	16	-	4
	CMI/2	128(1)^I	2(1)^I	<1(na) ^S	-(na)	4(1)^I	4(0.50) ^S	64(16)^A	8(0.50) ^S	-(na)	2(0.50) ^S	40
	CMI/4	128(1)^I	2(1)^I	<1(na) ^S	-(na)	4(1)^I	4(0.50) ^S	128(32)^A	16(1)^I	-(na)	2(0.50) ^S	30
CHL	0	64	4	8	64	64	64	256	64	-	32
	CMI/2	32(0.50) ^S	4(1)^I	1(0.13) ^S	64(1)^I	32(0.50) ^S	32(0.50) ^S	128(0.50) ^S	2(0.03) ^S	-(na)	32(1)^I	60
	CMI/4	64(1)^I	4(1)^I	2(0.25) ^S	64(1)^I	32(0.50) ^S	32(0.50) ^S	256(1)^I	4(0.06) ^S	-(na)	32(1)^I	40
ERY	0	128	0.50	0.50	-	16	16	256	32	-	32
	CMI/2	128(1)^I	<0.50(na) ^S	<0.50(na) ^S	128(na) ^S	8(0.50) ^S	8(0.50) ^S	128(0.50) ^S	1(0.03) ^S	128(na) ^S	16(0.50) ^S	90
	CMI/4	128(1)^I	<0.50(na) ^S	<0.50(na) ^S	128(na) ^S	8(0.50) ^S	8(0.50) ^S	256(1)^I	4(0.13) ^S	128(na) ^S	16(0.50) ^S	80
KAN	0	64	0.50	0.50	2	8	32	4	16	-	16
	CMI/2	32(0.50) ^S	<0.50(na) ^S	<0.50(na) ^S	<0.50(na) ^S	1(0.13) ^S	2(0.06) ^S	8(2)^I	4(0.25) ^S	-(na)	4(0.25) ^S	80
	CMI/4	64(1)^I	<0.50(na) ^S	<0.50(na) ^S	1(0.50) ^S	2(0.25) ^S	4(0.13) ^S	256(64)^A	8(0.50) ^S	-(na)	8(0.50) ^S	70
TET	0	16	32	2	64	32	32	8	2	8	32
	CMI/2	16(1)^I	16(0.50) ^S	1(0.50) ^S	8(0.13) ^S	16(0.50) ^S	4(0.13) ^S	8(1)^I	<0.50(na) ^S	4(0.50) ^S	8(0.25) ^S	80
	CMI/4	16(1)^I	32(1)^I	1(0.50) ^S	8(0.13) ^S	16(0.50) ^S	4(0.13) ^S	64(8)^A	<0.50(na) ^S	4(0.50) ^S	8(0.25) ^S	70
AMP	0	-	-	128	-	-	-	-	-	-	-
	CMI/2	-(na)	-(na)	128(1)^I	-(na)	-(na)	-(na)	-(na)	-(na)	-(na)	-(na)	00
	CMI/4	-(na)	-(na)	128(1)^I	-(na)	-(na)	-(na)	-(na)	-(na)	-(na)	-(na)	00
CEF	0	-	64	32	-	-	-	-	-	-	-
	CMI/2	-(na)	64(1)^I	32(1)^I	-(na)	-(na)	-(na)	-(na)	-(na)	-(na)	-(na)	00
	CMI/4	-(na)	64(1)^I	32(1)^I	-(na)	-(na)	-(na)	-(na)	-(na)	-(na)	-(na)	00

^aAntibiotics [TET tetracycline, CIP ciprofloxacin, NOR norfloxacin, KAN kanamycin, CHL chloramphenicol, ERY erythromycin, AMP ampicillin, CEF: cefepime]
^bBacterial strains: Escherichia coli [AG100, AG102, AG100Atet], Pseudomonas aeruginosa [PA124], Enterobacter aerogenes [CM64, EA27, EA289], Klebsiella pneumonia [KP55], Providencia stuartii [NAE16]
^cPBSS: percentage of bacteria strain on which synergism has been observed; (): FIC (Fractional Inhibitory Concentration) of the antibiotics after association with plants extract; S: Synergy, I: Indifference; na: not applicable; The values in bold represent the cases of synergy between extract and antibiotic; (-): >256 μg/mL

Back to article page

ISSN: 2662-7671

Contact us

Submission enquiries: bmccomplementarymedicineandtherapies@biomedcentral.com
General enquiries: info@biomedcentral.com