Skip to main content

Table 4 MIC (FIC) of different antibiotics in association with the extract of Xanthosoma mafaffa at MIC/2, MIC/4 against ten MDR bacteria strains

From: Antibacterial and antibiotic-modifying activities of three food plants (Xanthosoma mafaffa Lam., Moringa oleifera (L.) Schott and Passiflora edulis Sims) against multidrug-resistant (MDR) Gram-negative bacteria

Antibiotics

Bacterial strains, MIC (μg/mL) of antibiotics in the absence and presence of the extract

Extract concentration

PA124

AG100

AG102

AG100Atet

EA27

EA289

CM64

KP55

KP63

NEA16

PBSS (%)

CIP

0

16

0.50

0.50

-

1

1

0.50

2

-

1

 

CMI/2

16(1)I

0.50(1)I

<0.50(na) S

-(na)

0.25(0.25) S

0.50(0.50) S

1(2)I

<0.50(na) S

16(na) S

0.50(0.50) S

60

CMI/4

16(1)I

0.50(1)I

<0.50(na) S

-(na)

0.25(0.25) S

1(1)I

1(2)I

<0.50(na) S

16(na) S

1(1)I

40

NOR

0

128

2

1

-

4

8

4

16

-

4

 

CMI/2

128(1)I

2(1)I

<1(na) S

128(na) S

8(2)I

16(2)I

32(8)A

16(1)I

128(na)S

8(2)I

30

CMI/4

128(1)I

2(1)I

<1(na) S

128(na) S

32(8)A

16(2)I

32(8)A

16(1)I

-(na)

8(2)I

20

CHL

0

64

4

8

64

64

64

256

64

-

32

 

CMI/2

64(1)I

4(1)I

1(0.13) S

32(0.50) S

4(0.06) S

32(0.50) S

256(1)I

16(0.25) S

-(na)

16(0.50) S

60

CMI/4

64(1)I

4(1)I

2(0.25) S

64(1)I

16(0.25) S

32(0.50) S

256(1)I

16(0.25) S

-(na)

16(0.50) S

50

ERY

0

128

0.50

0.50

-

16

16

256

32

-

32

 

CMI/2

64(0.50) S

<0.50(na) S

<0.50(na) S

128(na) S

8(0.50) S

8(0.50) S

256(1)I

32(1)I

128(na) S

16(0.50) S

80

CMI/4

64(0.50) S

<0.50(na) S

<0.50(na) S

128(na) S

8(0.50) S

8(0.50) S

256(1)I

64(2)I

128(na) S

16(0.50) S

80

KAN

0

64

0.50

0.50

2

8

32

4

16

-

16

 

CMI/2

32(0.50) S

<0.50(na) S

<0.50(na) S

<0.50(na) S

4(0.50) S

8(0.25) S

2(0.50) S

16(1)I

-(na)

16(1)I

70

CMI/4

64(1)I

<0.50(na) S

1(2)I

1(0.50) S

8(1)I

8(0.25) S

4(1)I

16(1)I

-(na)

16(1)I

30

TET

0

16

32

2

64

32

32

8

2

8

32

 

CMI/2

8(0.50) S

16(0.50) S

<0.50(na) S

4(0.06) S

8(0.25) S

4(0.13) S

2(0.25) S

<0.50(na) S

1(0.13) S

4(0.13) S

100

CMI/4

16(1)I

32(1)I

1(0.50) S

4(0.06) S

8(0.25) S

16(0.50) S

2(0.25) S

<0.50(na) S

1(0.13) S

4(0.13) S

80

AMP

0

-

-

128

-

-

-

-

-

-

-

 

CMI/2

-(na)

-(na)

128(1)I

-(na)

-(na)

-(na)

-(na)

128(na) S

-(na)

-(na)

10

CMI/4

-(na)

-(na)

128(1)I

-(na)

-(na)

-(na)

-(na)

-(na)

-(na)

-(na)

00

CEF

0

-

64

32

-

-

-

-

-

-

-

 

CMI/2

-(na)

64(1)I

32(1)I

-(na)

-(na)

-(na)

-(na)

256(na) S

-(na)

-(na)

10

CMI/4

-(na)

64(1)I

32(1)I

-(na)

-(na)

-(na)

-(na)

-(na)

-(na)

-(na)

00

  1. aAntibiotics [TET tetracycline, CIP ciprofloxacin, NOR norfloxacin, KAN kanamycin, CHL chloramphenicol, ERY erythromycin, AMP ampicillin, CEF cefepime]
  2. bBacterial strains: Escherichia coli [AG100, AG102, AG100Atet], Pseudomonas aeruginosa [PA124], Enterobacter aerogenes [CM64, EA27, EA289], Klebsiella pneumonia [KP55], Providencia stuartii [NAE16]
  3. cPBSS: percentage of bacteria strain on which synergism has been observed; (): FIC (Fractional Inhibitory Concentration) of the antibiotics after association with plants extract; S: Synergy, I: Indifference; na: not applicable; The values in bold represent the cases of synergy between extract and antibiotic; (-): >256 μg/mL